ArticleNature microbiology2026
Gut microbiota-derived L-theanine promotes host branched-chain amino acid catabolism.
Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- A microbial L-theanine-BCAT2 axis rewires host BCAA catabolism.Science China. Life sciences · 2026Article
- Decoding the Gut-Fat-Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies.International journal of molecular sciences · 2026Review
- Goat gut microbiome as a reservoir for microorganism-encoded short peptides: regulation by host development age and nematode challenge.NPJ biofilms and microbiomes · 2026Article
- d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation.Science advances · 2026Article
- Machine learning and experiment reveals gut microbial predictors of functional fatty acids in pork.Food chemistry: X · 2026Article
- Early life nutritional imbalance impairs colonic epithelial regeneration through gut microbiota dysbiosis and metabolic suppression.The ISME journal · 2026Article
- Polyamines as a Universal Language of Host-Microbiota Symbiosis.Research (Washington, D.C.) · 2026Review
- Integrated multi-omics analysis reveals distinct microbiota-metabolite signatures and a novel HCN2-2-hydroxybutyric acid interaction in inflammatory bowel disease.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Elevated levels of serum branched-chain amino acids (BCAA) are linked to various metabolic disorders such as obesity, insulin resistance and type 2 diabetes. Although gut microbiota can regulate circulating BCAA levels via direct transformation, here we uncover an indirect mechanism that influences host BCAA metabolism. Comparisons between the metabolome and gut microbiota of germ-free and wild-type mice and pigs revealed Lactobacillus reuteri and its metabolite L-theanine to be associated with increased BCAA catabolism. This effect was reproduced by monocolonization of the animals with Lactobacillus reuteri or treatment with L-theanine. Experiments with pig cell lines showed that L-theanine enhanced the expression of branched-chain aminotransferases (BCATs), host enzymes involved in BCAA catabolism. Specifically, L-theanine promoted the expression of BCAT2 mRNA by suppressing its histone methylation and stabilizing the BCAT2 protein by inhibiting ubiquitination of specific lysine residues. Our findings provide a potential avenue for development of therapies against disorders associated with elevated BCAA levels.
Indexed as
Identifiers
41535710What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.