ArticleBMC cardiovascular disorders2026
Suboptimal lipid management is associated with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients with preserved ejection fraction: a cardiac magnetic resonance feature-tracking study.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundDespite guideline recommendations for stringent lipid-lowering targets, achievement rates in high cardiovascular risk patients with type 2 diabetes mellitus (T2DM) remain suboptimal, contributing to residual cardiovascular risk. This study aimed to investigate the relationship between achieving low-density lipoprotein cholesterol (LDL-C) target and subclinical cardiac function in patients with T2DM, utilising cardiac magnetic resonance feature tracking (CMR-FT).
methodsThis study recruited 118 patients with T2DM from January 2019 to December 2024. Differences in left ventricular function characteristics were compared between patients who achieved the LDL-C target and those who did not. Multivariable linear regression and logistic regression analyses were employed to investigate the association between lipid management and subclinical left ventricular dysfunction. The robustness of the analysis was verified through sensitivity analyses, including treating LDL-C as a continuous variable and excluding specific subpopulations.
resultsOf the 118 patients included in the study, 46 (38.9%) met the LDL-C target (LDL-C target achieved group), while 72 (61.1%) did not (LDL-C target nonachieved group). The nonachieved group demonstrated significant signs of adverse cardiac remodelling and impaired myocardial deformation (GLPS: -15.4% ± 3.1% vs. -17.3% ± 3.3%; RI: 0.84 [0.68, 1.08] vs. 0.77 [0.64, 0.88]; P < 0.05). After multivariable adjustment, the LDL-C target nonachieved was independently associated with GLPS impairment (β = -1.53, P = 0.009) and a 4.0-fold increased risk of GLPS abnormality (OR = 4.0, P = 0.006). Sensitivity analyses confirmed the robustness of the findings. When treating LDL-C as a continuous variable, it remained significantly inversely associated with GLPS (β = -0.61, P = 0.040). After excluding patients on PCSK9 inhibitors and those with extreme diabetes duration, failure to achieve the LDL-C target remained significantly associated with reduced GLPS (β = -1.71, P = 0.009) and an increased risk of abnormal GLPS (OR = 3.62, P = 0.021).
conclusionIn high cardiovascular risk patients with T2DM, suboptimal lipid management is associated with subclinical myocardial dysfunction. These results underscore the clinical importance of rigorous lipid control and highlight the potential role of CMR-FT in the early identification of patients who may benefit from intensified management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.