ArticleGenome biology2026
Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.
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Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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1citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
57 authors.
Wonji Kim *Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Xiaowei Hu *Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA.
Kangjin Kim *Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Sung ChunDivision of Genetics, Brigham and Women's Hospital, Boston, MA, USA.
Peter OrchardDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Dandi QiaoChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Aabida SaferaliChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Francois AguetIllumina Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA.
Lucinda Antonacci-FultonDepartment of Genetics, Washington University in St Louis, St Louis, MO, USA.
Pallavi P BalteThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Traci M BartzCardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.
Wardatul Jannat AnamikaChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Xiaobo ZhouChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
JunYi DuanChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
Harshavadran DoddapaneniBaylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
Shannon Dugan-PerezBaylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
Susan K DutcherDepartment of Genetics, Washington University in St Louis, St Louis, MO, USA.
Christian D FrazarUniversity of Washington, Seattle, WA, USA.
Stacey B GabrielBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sina A GharibCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Namrata GuptaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Brian D HobbsChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Silva KaselaNew York Genome Center, New York, NY, USA.
Laura R LoehrDivision of General Medicine and Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ginger A MetcalfBaylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
Donna M MuznyBaylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
Elizabeth C OelsnerDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Joshua SmithNorthwest Genomic Center, University of Washington, Seattle, WA, USA.
Tamar SoferDivision of Sleep and Circadian Disorder, Brigham and Women's Hospital, Boston, MA, USA.
Hanfei XuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Bing YuDepartment of Epidemiology, School of Public Health, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
David ZhangDepartment of Medicine and Institute for Genomic Medicine, Irving Medical Center, Columbia University, New York, NY, USA.
John ZinitiChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA.
April P CarsonDepartment of Medicine, University of Mississippi, Jackson, MS, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health at Houston, Houston, TX, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ravi KalhanDepartment of Preventive Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Robert KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Tuuli LappalainenNew York Genome Center, New York, NY, USA.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, NC, USA.
Alanna C MorrisonHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
George T O'ConnorPulmonary Center, Boston University School of Medicine, Boston, MA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Stephen S RichDepartment of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Edwin K SilvermanChanning Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Ani Manichaikul *Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA. amanicha@virginia.edu.
Michael H Cho *Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. remhc@channing.harvard.edu.
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2004 to 2005
$111.5MLarge Scale Sequencing at BCM-HGSCU54HG003273 · BAYLOR COLLEGE OF MEDICINE · 2004 to 2005
$63.6MUCLA Clinical and Translational Science InstituteUL1TR001881 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$9.9MPilot & Feasibility ProgramP30DK063491 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2003 to 2025
$5.4MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$3.8MPrecision phenotyping of emphysema in the elderly: the MESA Lung StudyR01HL077612 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2004 to 2025
$3.7MExceptional aging: 12 year trajectories to functionR01AG023629 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2005
$2.6MCombined Cardiopulmonary Failure in COPD: SPIROMICS HFR01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2022 to 2022
$2.3MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Susan S. Redline · 2022 to 2023
$2.0MEPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMR01HL059367 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1998 to 2005
$1.9MChicAgo Center for Health and EnvironmenT (CACHET)P30ES027792 · UNIVERSITY OF CHICAGO · 2025 to 2025
$1.6MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$1.5MIntramural NIH HHS Z01 ES043012NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U24 HG008956NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003273NHGRI NIH HHS UM1 HG008898NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201500015CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K01 HL135405NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL075478NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL098433NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113264NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL153248NHLBI NIH HHS R35 HL135818NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIEHS NIH HHS HHSN268201600033CNIEHS NIH HHS P30 ES027792NIMHD NIH HHS HHSN268201800013I
Abstract
backgroundWhole genome sequence (WGS) data in multi-ancestry samples supports discovery of low-frequency or population-specific genetic variants associated with chronic obstructive pulmonary disease (COPD) and lung function.
resultsWe performed single variant, structural variant, and gene-based analysis of pulmonary function (FEV
conclusionsLarge-scale multi-ancestry WGS analysis improves variant discovery and fine-mapping resolution for lung function and COPD and highlights biologically relevant genes and pathways.
Indexed as
LungPulmonary Disease, Chronic ObstructiveWhole Genome SequencingAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedQuantitative Trait LociRespiratory Function TestsColocalization with molecular QTLsCOPDCRISPR knockdownFine-mappingLung functionLung tissue single-cell RNA-seq validationMulti-ancestry GWAS
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