Evidence map›Paper›PMID 41535920›Full record

ArticleEnvironmental health : a global access science source2026

Residential proximity to active and abandoned oil and gas development and risk of childhood Ewing sarcoma in California.

Cassandra J Clark, Nicholaus Johnson, Rong Wang, Eric C Stewart, Logan G Spector, Joseph L Wiemels, Catherine Metayer, Nicole C Deziel, Xiaomei Ma

Abstract read
In one paragraph

Article in Environmental health : a global access science source, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cassandra J ClarkDivision of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA. clar1168@umn.edu.
Nicholaus JohnsonDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Rong WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Eric C StewartDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Logan G SpectorDivision of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Nicole C DezielDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Funding

Translational Pediatric Cancer Epidemiology Research Training GrantT32CA099936 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Logan G. Spector · 2004 to 2026
$5.1M
The Yale Cancer Prevention and Control Training ProgramT32CA250803 · NCI · YALE UNIVERSITY · PI Melinda L Irwin, Xiaomei Ma · 2020 to 2026
$2.3M
NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS T32 CA099936NCI NIH HHS T32 CA250803NCI NIH HHS T32CA250803, T32CA099936
6 · The paper itself

Abstract

backgroundOil and gas development (OGD) has been linked to increased pediatric cancer risk, but the literature to date is focused on hematologic malignancies and active wells. The emergence of suspected clusters of cancers such as Ewing sarcoma in children living near OGD and widespread presence of abandoned wells warrants investigation.

methodsThis study included 558 children born in California (1982–2015) reported to the California Cancer Registry with a diagnosis of Ewing sarcoma at 0–19 years (1988–2015), and 27,800 cancer-free controls frequency-matched to cases on birth-year (50:1 ratio). We used birth address to assign prenatal OGD exposure to active (drilled or producing) and plugged/abandoned wells separately with inverse distance-squared weighted well counts at 5 and 10 km buffer sizes from three months before conception to birth. We evaluated potential exposure disparities and estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between prenatal OGD exposure and Ewing sarcoma risk using multivariable logistic regression.

resultsHispanic children were significantly more likely to be exposed to both active and abandoned OGD within 10 km than non-Hispanics (40% vs. 23% and 14% vs. 6%, respectively). There were no associations between prenatal exposure to active OGD within 10 km and Ewing sarcoma risk (OR: 0.88 [95% CI: 0.72–1.08]). However, children within 10 km of abandoned wells were 1.27 [0.96–1.66] times as likely to develop Ewing sarcoma as unexposed children; when stratified by ethnicity, this association appeared in Hispanic children only (1.33 [0.95–1.88]).

conclusionWe did not identify an association between exposure to active OGD and pediatric Ewing sarcoma risk in California. Abandoned wells were associated with a suggestive increase in risk among Hispanic children, who were also more likely to be exposed to any OGD activity than non-Hispanic children. This disparity could have implications for other health outcomes including childhood cancers.

Indexed as

Bone NeoplasmsEnvironmental ExposureOil and Gas IndustryPrenatal Exposure Delayed EffectsSarcoma, EwingAdolescentCaliforniaCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalePregnancy

Identifiers

PMID41535920
PMCPMC12888232

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.