ArticleBritish journal of clinical pharmacology2026
Population pharmacokinetics and dose-response relationships of mitoxantrone in children with acute myeloid leukaemia.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Population pharmacokinetics and dose-response relationships of mitoxantrone in children with acute myeloid leukaemia.British journal of clinical pharmacology · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundInformation on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data-informed assessment of dosing.
methodsA total of 282 plasma samples from 44 patients aged 0.9-17 years, receiving intravenous mitoxantrone at doses of 12 mg/m
resultsA two-compartment model with fixed allometric scaling best described the data, with a final population estimated CL of 39.1 L/h (residual standard error 9.6%) observed for a patient weighing 27.5 kg. Infants receiving mg/kg dosing exhibited lower AUC values (192 ± 75 μg·h/L) than the mg/m
conclusionThis study provides novel insights into the pharmacokinetics of mitoxantrone in children. Infant patients receiving body weight-based dosing regimens may be at risk of suboptimal drug exposure, and many of these patients may tolerate higher mitoxantrone doses in line with older children. This trial was registered with the EU Clinical Trials Register (EudraCT number 2014-005066-30).
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Registered trials
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