[Effect of Blood Biochemical Indicators on Exercise Duration in Patients With Stages 3-5 Chronic Kidney Disease: The Mediating Role of Physical Function Status].

Objective: To investigate the effects of blood biochemical indicators on physical functional status and exercise duration in patients with chronic kidney disease (CKD) in stages 3-5. Methods: A total of 156 patients with stages 3-5 CKD admitted to our hospital between March 2021 and February 2024 were enrolled in the study. General information questionnaires, the Karnofsky Performance Status (KPS) scale of functional status, and the International Physical Activity Questionnaire-Long Form (IPAQ-L) were used for data collection. Blood biochemical indicators were assessed through blood tests. Patients who engaged in physical activity meeting the recommended standards of the CKD clinical practice guidelines were defined as the high-level exercise group, while the others were defined as the low-level exercise group. Pearson correlation analysis was performed to examine the relationship between blood biochemical indicators, physical functional status, and exercise duration. Multiple linear regression was performed to identify factors influencing exercise duration. The SPSS macro program Process 4.1 was used to analyze the mediating effect. Results: The average KPS score of the 156 patients with stage 3-5 CKD was 77.03 ± 11.99, and the average weekly exercise duration was (71.67 ± 10.16) min. Compared with the high-level group, the low-level group had lower hemoglobin (Hb) ([94.76 ± 16.98] g/L) and serum albumin (Alb) ([30.96 ± 6.35] g/L) levels and a higher blood urea nitrogen (BUN) ([13.45 ± 3.28] mmol/L) level ( Conclusion: Hb, Alb, and BUN can directly affect the exercise duration of patients with CKD in stages 3-5, and can also indirectly affect the exercise duration of patients through physical functional status.