ReviewAIMS public health2025
A systematic review and meta analysis on the effect of vitamin D in preeclampsia and gestational diabetes mellitus in pregnancy.
Review in AIMS public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preeclampsia and gestational diabetes mellitus (GDM) are significant contributors to maternal and neonatal morbidity and mortality, particularly in low- and middle-income countries. Vitamin D might play a role in the pregnancy complication prevention. However, findings across studies remain inconsistent. In this review, we aimed to evaluate vitamin D deficiency effect on preeclampsia and GDM risks, and the effect of vitamin D supplementation during pregnancy in reducing preeclampsia and GDM incidences. Methods: We followed the PRISMA guidelines and registered the protocol with PROSPERO (CRD42024609276). Database PubMed, Scopus, and EBSCO-Medline were used to search cohort and randomized controlled trial (RCT) studies published between 1993 and 2025. Two reviewers independently assessed the article quality with the Joanna Briggs Institute checklists and extracted data. Meta-analyses were performed using RevMan 5.4. The results were reported in pooled odds ratios (OR) or standardized mean differences (SMD) with 95% confidence intervals. Results: A total of 52,372 participants from 24 studies were included in this review. Vitamin D supplementation appeared to reduce the preeclampsia risk by 42% (OR = 0.58; 95%CI: 0.43-0.78; I Conclusion: Vitamin D supplementation in pregnancy, especially in the first trimester, decreased preeclampsia and GDM risks, while vitamin D deficiency in pregnancy increased GDM risk but not preeclampsia. These findings support the potential benefit of vitamin D supplementation in the routine antenatal care to improve pregnancy outcomes.
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