Evidence map›Paper›PMID 41536960›Full record

ArticleEuropean heart journal open2026

Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research.

C Nina van der Wilt, Rogier J A Veltrop, Maaike H Janssens, Iara Bakker, Francesca Stillitano, Joost P G Sluijter, Linda W van Laake, Jolanda van der Velden, Eric Villard, Judith Montag and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CRISPR and the Future of Cardiac Disease Therapy: A New Genetic Frontier.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

C Nina van der WiltDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Rogier J A VeltropDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Maaike H JanssensDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Iara BakkerDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Francesca StillitanoDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Joost P G SluijterDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Linda W van LaakeDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-5027-0661
Jolanda van der VeldenDepartment of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-5224-5788
Eric VillardSorbonne Université, INSERM, UMRS 1166, 47-83, Boulevard de l'Hôpital, 75013 Paris, France.
Judith MontagDepartment of Human Medicine, Medical School Berlin, Rüdesheimer Str. 50, 14197 Berlin, Germany.
Chris DenningBiodiscovery Institute, University of Nottingham, Life Sciences Building University Park, NG7 2RD Nottingham, UK.ORCID https://orcid.org/0000-0003-0802-8617
J Peter van TintelenDepartment of Genetics, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Anneline S J M Te RieleDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-4694-4790
Pim van der HarstDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-2713-686X
Leon J SchurgersDepartment of Biochemistry, CARIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Frank G van SteenbeekDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Magdalena HarakalovaDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-7293-1029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clinical trialsCRISPR-CasGenome editingStandardized clinical reportingVariant pathogenicity

Identifiers

PMID41536960
PMCPMC12796640

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.