Evidence mapPaperPMID 41536971Full record

ArticleBioinformatics and biology insights2026

In Silico Identification of Lepiotaprocerin C as a Promising PIM-1 Kinase Inhibitor: An Integrated Docking, Molecular Dynamics, MM/PBSA, QSAR, and ADMET Study.

Keshava Ks, Faten Qais Ibraheem, Shankar Thapa, Somashekhar M Metri, Sadik Shaik, Santosh Prasad Chaudhary Kurmi, Abhishek Chowdhury, Vipin Kumar Mishra, Pramila T

Abstract read
In one paragraph

Article in Bioinformatics and biology insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keshava KsDepartment of Pharmacology, GM Institute of Pharmaceutical Sciences and Research, Davangere, India.ORCID https://orcid.org/0009-0002-1673-452X
Faten Qais IbraheemTechnical Institute of Pharmacy, Ishtar Medical Institute, Baghdad, Iraq.ORCID https://orcid.org/0000-0002-3802-9525
Shankar ThapaDepartment of Pharmaceutical Chemistry, East Point College of Pharmacy, Bengaluru, India.ORCID https://orcid.org/0000-0003-1801-5668
Somashekhar M MetriDepartment of Pharmaceutical Chemistry, BLDEA's Shri Sanganabasava Mahaswamiji College of Pharmacy and Research Centre, Vijayapur, India.
Sadik ShaikDepartment of Pharmacology, East Point College of Pharmacy, Bengaluru, India.ORCID https://orcid.org/0000-0003-0176-3504
Santosh Prasad Chaudhary KurmiDepartment of Pharmacy, Universal College of Medical Sciences, Bhairahawa, Nepal.ORCID https://orcid.org/0009-0007-0454-2471
Abhishek ChowdhuryDepartment of Chemistry, Faculty of Science, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Prayagraj, India.
Vipin Kumar MishraChemistry Division, School of Advanced Sciences and Languages, VIT Bhopal University, Bhopal, India.
Pramila TDepartment of Pharmaceutical Chemistry, Bharthi College of Pharmacy, Mandya, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proviral Integration site for Moloney murine leukemia virus-1 (PIM-1) kinase, a serine/threonine kinase overexpressed in various malignancies, plays a critical role in promoting cell survival and proliferation, making it a promising target for anticancer therapy. This study employed an integrated in silico approach to evaluate Lepiotaprocerin derivatives (A to L) from

Indexed as

Anticancer activitycell membrane permeabilityLepiotaprocerin Cmolecular dockingPIM kinase

Identifiers

PMID41536971
PMCPMC12796144

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.