ArticleiScience2026
Improvement of islet transplantation in prevascularized muscle sinus tracts.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to develop an optimal alternative site for islet transplantation, addressing the limitations of the current clinical standard, the intrahepatic site. In this study, prevascularized muscle sinus tracts (MSTs) in mice were created by implanting and then removing polyamide rods, leveraging a controlled foreign body reaction to generate a highly vascularized, porous collagen matrix. Transplantation of 350 syngeneic islets into these MSTs consistently reversed diabetes in mice, achieving long-term normoglycemia for over 180 days, with efficacy comparable with kidney capsule transplantation. The approach also supported the survival of human islets in immunodeficient mice and demonstrated feasibility in a porcine autotransplantation model. This work establishes the MST as a simple, effective, and clinically promising strategy that enhances islet engraftment through localized prevascularization, potentially improving the therapeutic outcomes of islet transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.