Evidence map›Paper›PMID 41536998›Full record

ArticleiScience2026

Spectrin condensates provide a nidus for assembling the axonal membrane-associated periodic skeleton.

Nicholas P Boyer, Rohan Sharma, Theresa Wiesner, Christopher Parperis, Antoine Delamare, Florence Pelletier, Nicolas Jullien, Anshul M Bhatt, Leonardo A Parra-Rivas, Patrick J Kearney and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Nicholas P BoyerDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Rohan SharmaDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Theresa WiesnerAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Christopher ParperisAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Antoine DelamareAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Florence PelletierAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Nicolas JullienAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Anshul M BhattDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Leonardo A Parra-RivasDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Patrick J KearneyDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Farbod ShavarebiDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Christophe LeterrierAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France.
Subhojit RoyDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.

Funding

Slow axonal transport of cytosolic cargoes by dynamic-recruitment - a new trafficR01NS075233 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ROY, SUBHOJIT · 2012 to 2023
$3.4M
NINDS NIH HHS R01 NS075233
6 · The paper itself

Abstract

In axons, α/β-spectrins, adducin, and actin filaments assemble into a lattice underneath the plasma membrane, but the mechanistic events leading to this membrane-associated periodic skeleton (MPS) are unclear. Visualizing MPS-components in developing axons, we found distal focal patches containing spectrins and adducin (but sparse actin filaments) with biophysical properties reminiscent of biomolecular condensation. Overexpressing spectrin repeats - constituents of α/β-spectrins - in heterologous cells triggered condensate formation, and preventing the association of βII-spectrin with actin filaments or membranes also facilitated condensation. Introducing a stretch of spectrin-repeats in neurons before MPS establishment triggered ectopic condensate-like structures in the soma and disrupted the axonal lattice, advocating a functional role for biomolecular condensation. We propose a condensation-assembly model where spectrin-repeats trigger focal phase separated condensates, providing a nidus for MPS assembly that recruits actin filaments to ultimately generate the stable lattice. Our overall model is supported by recent studies showing phase-separation via coiled-coil domains and recruitment/polymerization of actin by other condensate-forming proteins.

Indexed as

Cell biologyMolecular neuroscienceNeuroscience

Identifiers

PMID41536998
PMCPMC12796769

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.