Evidence map›Paper›PMID 41537000›Full record

ArticleiScience2026

3D-printed scaffold loaded with baicalin exosomes promotes bone defect repair via mediating PRRX2 to alleviate inflammation.

Haotian Zhu, Kai Cheng, Mingwei Tian, Yuanhao Peng, Yadi Zhang, Han Yan, Shaoxing Fan, Bo Shang, JiaYi Wu, Huanwen Ding and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haotian ZhuSchool of Medicine, South China University of Technology, Guangzhou 510006, China.
Kai ChengThe Guangzhou First People's Hospital, Guangzhou 510180, Guangdong, China.
Mingwei TianSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China.
Yuanhao PengSchool of Medicine, South China University of Technology, Guangzhou 510006, China.
Yadi ZhangSchool of Medicine, South China University of Technology, Guangzhou 510006, China.
Han YanThe Guangzhou First People's Hospital, Guangzhou 510180, Guangdong, China.
Shaoxing FanThe Guangzhou First People's Hospital, Guangzhou 510180, Guangdong, China.
Bo ShangThe Guangzhou First People's Hospital, Guangzhou 510180, Guangdong, China.
JiaYi WuGuangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China.
Huanwen DingSchool of Medicine, South China University of Technology, Guangzhou 510006, China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic nonunion of bone defects remains a significant challenge in orthopedic treatment. Artificial bone graft materials are expected to solve this problem due to their suitable degradation rate and good osteoconductivity. However, ROS and inflammation within the defect environment are important causes of implant failure. Exosomes derived from different preconditioned bone mesenchymal stem cells (BMSCs) have shown great potential in the treatment of various diseases. Here, we developed a 3D-β-TCP@BA-BMSC-exos scaffold that loaded baicalin-pretreated BMSC exosomes (BA-BMSC-exos) on a 3D-printed β-tricalcium phosphate scaffold (3D-β-TCP) for bone defect repair.

Indexed as

Biological sciencesEngineering

Identifiers

PMID41537000
PMCPMC12796540

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.