Trial reportJournal of animal science2026
Non-nutritive sweeteners improve growth, reduce diarrhea, and modulate intestinal and systemic metabolism in weaned pigs.
Trial report in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Early weaning improves swine productivity but induces stress that impairs growth, compromises intestinal health, and increases diarrhea. A total of 288 weaned pigs (21 ± 1 d; PIC 800× Yorkshire; initial body weight (BW) 6.21 ± 0.45 kg) were used in a randomized complete block design, with initial BW as the blocking factor and pen as the experimental unit (48 pens; 6 pig/pen). Pigs were assigned to one of four dietary treatments: a nursery basal diet (control; CON), CON supplemented with 150 mg/kg sucralose (SCL). CON supplemented with 30 mg/kg neotame (NEO) or CON supplemented with 50 mg/kg carbadox (CBX). This study investigated the effects of dietary SCL or NEO supplementation on growth performance, diarrhea incidence, immune responses, intestinal development, and serum metabolites in weaned pigs. Pigs supplemented with SCL tended to increase (P = 0.093) average daily gain (ADG) from day 0 to 7 and increased (P < 0.05) average daily feed intake (ADFI) during phase 1 compared with CON. Pigs supplemented with NEO tended to increase (P = 0.083, P = 0.090) BW on days 7 and 14 and ADG (P = 0.053), and increased ADFI (P < 0.05) during phase 1 compared with CON. Both NEO (P < 0.05) and SCL (P < 0.10) reduced diarrhea frequency during phase 1 and across the experimental period compared with CON. SCL improved villus height-to-crypt depth ratio (P < 0.05), and reduced crypt depth (P < 0.05) compared with CON on day 14. SCL downregulated (P < 0.05) tight junction protein 1 (TJP1) expression compared with CBX on day 28. Untargeted serum metabolomics revealed that both SCL and NEO altered amino acid, nucleoside, antioxidant, and lipid metabolic pathways relative to CON. On day 14, SCL altered β-alanine and glutathione metabolism, whereas NEO modulated amino acid-derived metabolites. By day 28, SCL modulated purine, D-amino acid, and ether lipid metabolism, while NEO was associated with taurine and hypotaurine metabolism. These findings indicate that SCL and NEO improve growth performance and reduce post-weaning diarrhea, with SCL additionally enhancing intestinal structure and barrier-related markers, while NEO may act through palatability enhancements or microbiota-associated metabolic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.