Evidence map›Paper›PMID 41537425›Full record

ArticleeLife2026

Rtf1-dependent transcriptional pausing regulates cardiogenesis.

Adam D Langenbacher, Fei Lu, Luna Tsang, Zi Yi Stephanie Huang, Benjamin Keer, Zhiyu Tian, Alette Eide, Matteo Pellegrini, Haruko Nakano, Atsushi Nakano and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Adam D LangenbacherDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0002-3752-0208
Fei LuDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Luna TsangDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Zi Yi Stephanie HuangDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Benjamin KeerDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Zhiyu TianDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Alette EideDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-9355-9564
Haruko NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-5807-9127
Atsushi NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-5702-5039
Jau-Nian ChenDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-8807-3607

Funding

Rtf1-dependent transcriptional regulation of heart developmentR01HL140472 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, TRINH, LE A. · 2018 to 2021
$1.6M
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regenerationR01HL155905 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL140472NHLBI NIH HHS R01 HL155905NIH HHS R01 HL140472NIH HHS R01 HL155905
6 · The paper itself

Abstract

Transcriptional pause-release critically regulates cellular RNA biogenesis, yet how dysregulation of this process impacts embryonic development is not fully understood. Rtf1 is a multifunctional transcription regulatory protein involved in modulating promoter-proximal pausing of RNA Polymerase II (RNA Pol II). Using zebrafish and mouse as model systems, we show that Rtf1 activity is essential for the differentiation of the myocardial lineage from mesoderm. Ablation of

Indexed as

HeartTranscription FactorsTranscription, GeneticZebrafish ProteinsAnimalsChromosomal Proteins, Non-HistoneGene Expression Regulation, DevelopmentalMiceMyocytes, CardiacRNA Polymerase IITranscriptional Elongation FactorsZebrafishChromosomal Proteins, Non-HistoneRNA Polymerase IISPT5 transcriptional elongation factorTranscriptional Elongation FactorsTranscription FactorsZebrafish Proteinscardiogenesisdevelopmental biologylateral plate mesodermmousePAF1 complexpromoter-proximal pausingRtf1transcription regulationzebrafish

Identifiers

PMID41537425
PMCPMC12807453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.