Evidence map›Paper›PMID 41537736›Full record

ArticleMolecular biology of the cell2026

Rab4 spatially and functionally converges with Rab7 in the degradative endolysosomal network.

Stephen M Farmer, Shiyu Xu, Yue Yu, Xin Ye, Haoyi Yang, Jing Cai, Beatriz Rios, Wen-Wen Lin, Daniela Covarrubias, Vicky Chuong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Stephen M FarmerCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Shiyu XuCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Yue YuCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Xin YeCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Haoyi YangCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Jing CaiCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Beatriz RiosCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Wen-Wen LinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030.
Daniela CovarrubiasProgram in Biosciences, Rice University, Houston, TX, 77005.
Vicky ChuongProgram in Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, 77030.
Lili YeCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
German ZylberbergDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, 77030.
Charissa WangProgram in Biosciences, Rice University, Houston, TX, 77005.
Erin Furr-StimmingDepartment of Neurology, HDSA Center of Excellence, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, 77030.
Qingchun TongCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.
Oguz KancaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030.
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030.
Travis I MooreProgram in Molecular and Translational Biology, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, 77030.
Sheng ZhangCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, 77030.

Funding

The Roles of Huntingtin Associated Protein 40 in Huntingtin Functions and Huntington's Disease PathogenesisR01NS110943 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, SHENG · 2019 to 2023
$2.0M
Mechanoregulation of the Leukocyte Specific Integrin LFA-1 by the Actin CytoskeletonK01HL143111 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2018 to 2022
$856k
Decoding Force Transduction Mechanisms of Leukocyte Specific Integrin LFA-1 in Immune ResponsesR03HL180981 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2025 to 2025
$234k
The role of Huntingtin in endolysosomal trafficking and Huntington's disease pathogenesisF99NS141400 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FARMER, STEPHEN M · 2024 to 2025
$77k
NHLBI NIH HHS K01 HL143111NHLBI NIH HHS R03 HL180981NINDS NIH HHS F99 NS141400NINDS NIH HHS R01 NS110943
6 · The paper itself

Abstract

Rab GTPases are key regulators of endosomal trafficking in eukaryotes. In mammalian cells, Rab4 and Rab7 were shown to localize to distinct compartments, with Rab4 on early endosomes for fast recycling and Rab7 on late endosomes for degradation. Here, we show that in

Indexed as

Drosophila ProteinsEndosomesLysosomesrab4 GTP-Binding Proteinsrab GTP-Binding ProteinsAnimalsDrosophilaDrosophila melanogasterProtein TransportProteolysisrab5 GTP-Binding Proteinsrab7 GTP-Binding ProteinsDrosophila Proteinsrab4 GTP-Binding Proteinsrab5 GTP-Binding Proteinsrab7 GTP-Binding Proteinsrab GTP-Binding Proteins

Identifiers

PMID41537736
PMCPMC12911854

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.