ArticleInflammation2026
Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway.
Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Acute viral myocarditis (AVM) is a leading cause of sudden cardiac death in young individuals, and currently, there are no effective targeted clinical treatments. The role and underlying mechanisms of β2-adrenergic receptors (β2-AR) in the pathogenesis of viral myocarditis remain inadequately understood. We found that β2-AR expression reduced in monocyte-derived macrophage (MoMFs). Activation of β2-AR significantly alleviated inflammatory responses, reduced fibrosis, and improved cardiac function in AVM mice. The protective effects of activating β2-AR on AVMs were mediated by reducing MoMFs infiltration into the heart, promoting M2 phenotype, decreasing the circulating Ly6C
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