ArticleVeterinary research communications2026
Effects of cecropin A on cytokine production and tight junction protein expression in chicken ileal explant cultures.
Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Investigation of the Immunomodulatory Effects of Combined Prebiotic, Probiotic, and Postbiotic Mixtures in Chicken Ileal Explant Cultures.Animals : an open access journal from MDPI · 2026Article
- Livestock immunomodulators as alternatives to antimicrobials - a roadmap for the fight against drug resistance.BMC veterinary research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
In an era of antimicrobial resistance (AMR), identifying alternatives to conventional antibiotics in livestock farming is vital for veterinary medicine and public health. Due to the constant exposure to pathogens and the need for optimal productivity, maintaining gut homeostasis is essential in poultry. Therefore, investigating antimicrobial alternatives that can support gut health is of key importance. Host defense peptides (HDPs) have been identified as promising candidates due to their beneficial effects on the gut; however, there is still much to clarify regarding the individual peptides' mechanism of action. In the present study, the HDP cecropin A (CecA) was applied to chicken-derived ex vivo ileal explant cultures to examine its impact on immune response and tight junction (TJ) protein expression. CecA was applied at 3.125 and 6.25 µg/mL concentrations, either alone (Cec-low and Cec-high) or in polyinosinic-polycytidylic acid (Poly I:C, 50 µg/mL)-induced inflammatory conditions (PI:C + Cec-low and PI:C + Cec-high). The experiment revealed that CecA had no impact on cell viability, as reflected by unchanged metabolic activity and extracellular lactate dehydrogenase activity. Regarding the immune state, Cec-high and PI:C + Cec-high increased the production of interleukin (IL)-2, whereas IL-6 concentration was decreased by PI:C + Cec-low treatment. Furthermore, Cec-high elevated the intracellular expression of the TJ protein claudin-3. In conclusion, CecA displayed immunomodulatory activity in chicken intestinal cells and supported epithelial integrity without exerting cytotoxic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.