Evidence map›Paper›PMID 41537945›Full record

ArticleClinical rheumatology2026

Diagnostic value of lung ultrasound vs. quantitative computed tomography in connective tissue disease-associated interstitial lung disease: a preliminary study.

Xiaokun Xin, Meng Huang, Hui Yuan, Li Zhang, Shan Dang, Guoqin Huang, Nan Yu

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaokun XinSchool of Medical Technology, Shaanxi University of Chinese Medicine, Xixian Avenue, Fengxi New City, Xixian New Area, Xian Yang, Shaanxi Province, 712046, China.
Meng HuangDepartment of Ultrasound Medicine, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Hui YuanDepartment of Rheumatology Immunohematology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Li ZhangSchool of Medical Technology, Shaanxi University of Chinese Medicine, Xixian Avenue, Fengxi New City, Xixian New Area, Xian Yang, Shaanxi Province, 712046, China.
Shan DangDepartment of Medical Imaging, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Guoqin HuangDepartment of Ultrasound Medicine, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Nan YuSchool of Medical Technology, Shaanxi University of Chinese Medicine, Xixian Avenue, Fengxi New City, Xixian New Area, Xian Yang, Shaanxi Province, 712046, China. yunan0512@sina.com.ORCID http://orcid.org/0000-0001-8481-8819

Funding

Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education No. 24JP049Scientific Research Project of the Education Department of Shaanxi Province No. 24JK0401
6 · The paper itself

Abstract

purposeTo evaluate the utility of modified lung ultrasound (LUS) and quantitative computed tomography (QCT) in assessing connective tissue disease-associated interstitial lung disease (CTD-ILD) and their correlations with high-resolution computed tomography (HRCT) of the chest.

methodsBetween October 2023 and 2024, 77 hospitalized CTD patients (57 CTD-ILD, 20 controls) who had undergone or were scheduled for chest HRCT also received LUS during their hospitalization, ensuring both assessments were completed within 1 week. The LUS and HRCT results were evaluated using modified LUS scores and Warrick scores, respectively. HRCT results were analyzed quantitatively using the "Dexin-FACT" automated analysis software.

resultsSignificant differences were observed in all LUS parameters and most QCT parameters between groups (P < 0.01), with significant correlations to ILD severity stratification (P < 0.05). Univariate analysis identified modified LUS scores, LAA

conclusionModified LUS shows potential as a practical tool for CTD-ILD detection, outperforming QCT parameters in diagnostic agreement with HRCT. These preliminary findings support LUS as an effective adjunct for CTD-ILD assessment. Key Points • Modified lung ultrasound scores outperformed traditional ultrasound metrics in distinguishing connective tissue disease-associated interstitial lung disease severity and showed the strongest predictive association with disease presence. • Significant differences in lung ultrasound and quantitative CT parameters were observed between connective tissue disease-associated interstitial lung disease and non-interstitial lung disease groups, correlating with disease progression and severity stratification. • Modified lung ultrasound demonstrated superior specificity to quantitative CT in detecting connective tissue disease-associated interstitial lung disease, highlighting its potential as a practical, non-invasive adjunct to HRCT.

Indexed as

Connective Tissue DiseasesLungLung Diseases, InterstitialTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedSeverity of Illness IndexUltrasonographyB-linesConnective tissue diseasesInterstitial lung diseaseLung ultrasoundQuantitative computed tomography

Identifiers

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.