Trial reportMedicine and science in sports and exercise2026
Exercise Training Reduces Cerebrovascular Impedance in Patients with Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial.
Trial report in Medicine and science in sports and exercise, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise Training for Cerebrovascular and Cognitive Health in Adults at Risk of Cognitive Decline: A Scoping Review of Healthcare Translation and Evidence Gaps.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionIn patients with amnestic mild cognitive impairment (aMCI), cerebrovascular impedance modulus ( Z ) was higher than in cognitively normal peers, which is associated with brain hypoperfusion. While 1 yr of moderate-to-vigorous aerobic exercise training (AET) reduced Z in cognitively normal older adults, the effects of AET on aMCI remain unknown.
methodsSeventy patients with aMCI were randomized into 1 yr of AET ( N = 31) or stretching and toning (SAT, N = 39). At baseline, midpoint (6 months), and trial completion (12 months), Z was assessed using transfer function analysis between carotid arterial pressure and cerebral blood flow (CBF) velocity measured simultaneously via applanation tonometry and transcranial Doppler in the middle cerebral artery, respectively. Total CBF was measured as the sum of the bilateral internal carotid and vertebral arterial flow via duplex ultrasonography.
resultsThe AET group exhibited gradual, significant reductions in Z at 6 months ( P = 0.008 vs baseline) and 12 months ( P < 0.001 vs baseline; P < 0.001 vs 6 months). In the SAT group, although Z decreased during the first 6 months ( P < 0.001 vs baseline), it was maintained over the following 6 months. Repeated-measures correlation analyses revealed inverse relationships between Z and total CBF as well as cerebrovascular conductance in the AET group ( rrm = -0.503, P = 0.008; rrm = -0.404, P = 0.037, respectively), but not in the SAT group. In exploratory sex-stratified analyses, women exhibited continued reductions in Z across 12 months regardless of training modality, whereas men demonstrated a plateau after 6 months.
conclusionsThese findings suggest that in patients with aMCI, AET reduces Z , which is associated with higher brain perfusion and cerebrovascular conductance. Sex-stratified analyses further suggested that women may experience greater improvements in Z than men across 1 yr of training.
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