ArticlePediatric research2026
Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Prenatal metabolic and mental health exposures and the association with neonatal brain dynamics.Pediatric research · 2026Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated pre-pregnancy body mass index (BMI) and perinatal depressive symptoms have been linked to neonatal alterations in brain structure and function. This study examined associations between neonatal functional brain dynamics, maternal BMI, and perinatal depressive symptoms measured by the Edinburgh Postnatal Depression Scale (EPDS) in a community-based, largely low-risk cohort.
methodsFuncitonal MRI and Leading Eigenvector Analysis (LEiDA) were applied in a neonatal cohort (N = 437; 236 males; mean gestational age 39.6 weeks) from the developing Human Connectome Project. We assessed whether neonatal brain-state probabilities related to maternal BMI and EPDS scores (M = 5.6, SD = 4.3), testing main effects and, separately, their interaction. The sample included 291 healthy-weight (BMI < 25), 98 overweight (25 BMI < 30), and 48 obese (BMI 30) mothers.
resultsEPDS scores were low in this cohort and did not demonstrate associations with brain states or a significant BMI × EPDS interaction. Higher maternal pre-pregnancy BMI was negatively associated with the stability of a functional network encompassing superior frontal, superior parietal, and temporal regions (ß = -0.129, p = 0.006).
conclusionAs this network is normally recruited more with age, reduced stability suggests slowed maturation of fronto-parieto-temporal systems and may signal early risk for later behavioral challenges. IMPACT: Higher maternal pre-pregnancy BMI is associated with reduced stability in a neonatal frontoparietal brain state, characterized by coordinated activity in frontal, parietal, and temporal regions. This state is one of six distinct dynamic connectivity patterns identified, reflecting core neonatal resting-state networks. The association was robust across multiple analytic models and clustering solutions. No significant effects were found for maternal depressive symptoms. These findings underscore the selective impact of maternal metabolic health on early brain organization, suggesting prenatal influences on the functional architecture of the newborn brain that may shape long-term neurodevelopmental trajectories.
Identifiers
41540202What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.