In one paragraphArticle in Molecular systems biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Yu-Long Zhao *Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.ORCID http://orcid.org/0009-0009-9091-8766 Yi-Ming Zhao *Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University Health Science Center, Peking University, 100191, Beijing, China.ORCID http://orcid.org/0009-0005-3462-6524 Ning Yang *Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.ORCID http://orcid.org/0009-0000-3329-8657 Si-Nan Ma *Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.ORCID http://orcid.org/0009-0005-1193-4882 Rui-Jia WangDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University Health Science Center, Peking University, 100191, Beijing, China.
Gui-Hai FengKey Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China. fenggh@ioz.ac.cn.ORCID http://orcid.org/0000-0002-8726-1734 Zhi-Kun LiKey Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China. lizhk58@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-0542-2339 Wei LiKey Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China. liwei@ioz.ac.cn.ORCID http://orcid.org/0000-0001-7864-404X Li-Bin WangDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University Health Science Center, Peking University, 100191, Beijing, China. wanglibin@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-2462-5342 Funding
Ministry of Science and Technology of the People's Republic of China (MOST) 2022YFA1103600Ministry of Science and Technology of the People's Republic of China (MOST) 2024YFA0917403MOST | National Natural Science Foundation of China (NSFC) 32225030MOST | National Natural Science Foundation of China (NSFC) 32470910national health commission key laboratory of birth defects prevention NHCKLBDP202409| Natural Science Foundation of Beijing Municipality () 7242083| Natural Science Foundation of Beijing Municipality () Z230011
6 · The paper itselfAbstract
Why eukaryotic genomes are universally divided among multiple chromosomes remains an unresolved question. Although yeast and mouse cells can tolerate chromosomal fusions without impairing viability, we show here that chromosome length in mammalian cells is constrained by a biophysical limit governed by spindle geometry. Using engineered mouse cells carrying fused chromosomes of defined sizes, we identify ~308 Mb as the maximal length tolerated for faithful mitosis. Chromosomes exceeding this threshold disrupt segregation, leading to daughter cell re-coalescence and polyploidization. Aurora B kinase regulates this process by modulating spindle elongation; its inhibition induces mitotic failure even in chromosome configurations within the tolerated threshold of ~308 Mb. These findings explain the structural basis for genome fragmentation in animals and reveal a general mechanism linking chromosome size, spindle dynamics, and genome stability.
Indexed as
ChromosomesChromosomes, MammalianMitosisSpindle ApparatusAnimalsAurora Kinase BChromosome SegregationGenomic InstabilityMicePolyploidyAurkb protein, mouseAurora Kinase BChromosomal TranslocationsChromosome LengthMitosisPolyploidizationSpindle
Identifiers
PMID41540256
PMCPMC13047055
What Socratic holds
Textmetadata
LicenceCC BY
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