Trial reportBMC cardiovascular disorders2026
Remote ischemic conditioning combined with transcutaneous vagus nerve stimulation reduces reperfusion injuries and improves cardiac function in acute ST-segment elevation myocardial infarctions.
Trial report in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate whether transcutaneous vagus nerve stimulation (TVNS) combined with left upper limb remote ischemic conditioning (RIC) before primary percutaneous coronary intervention (PCI) in patients with an acute ST-segment elevation myocardial infarction (STEMI) can reduce reperfusion injury and improve cardiac function.
methodsOne hundred and thirty-two patients with STEMI were randomly assigned to three different groups—Control, TVNS, and Combined (RIC combined with TVNS) before PCI. The groups were compared by calculating and comparing the area under curve (AUC) of a CK-MB test within 72 h of incidence, the severity of ventricular arrhythmias (VAs) within 24 h after reperfusion, and left ventricular ejection fraction (LVEF) via echocardiography seven days after reperfusion.
resultsCompared with the control group, the combined group demonstrated significantly decreased areas under the curve (AUCs). Specifically, the incidence of VAs within 24 h after reperfusion and BNP levels seven days post-reperfusion were significantly reduced, while the LVEF values at seven days exhibited a significant improvement (P < 0.05).In contrast, when compared with the control group, the group receiving only TVNS showed a reduction in the incidence of VAs within 24 h after reperfusion. Although the AUC test presented a decreasing trend, the difference was not statistically significant. Additionally, BNP levels and LVEF values in this group did not show significant improvements (P > 0.05).
conclusionsWhen administered alone, TVNS treatment significantly reduced the incidence of ventricular arrhythmias (VAs) after reperfusion. However, in the acute phase post-reperfusion, there was no significant difference in myocardial infarct size or left ventricular systolic function, despite a tendency towards improvement. In contrast, the combination of TVNS and RIC treatment led to improvements in left ventricular systolic function, reductions in myocardial infarct size, and decreases in the incidence of VAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.