Evidence map›Paper›PMID 41540433›Full record

ArticleRespiratory research2026

Activating KRAS mutations mark premalignant cystic structures in congenital pulmonary airway malformations.

Cathy van Horik, Floor Benthem, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Wilfred F J van IJcken, Rene M H Wijnen, Marco Schnater, Robbert J Rottier

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Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Cathy van HorikDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Floor BenthemDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Marjon Buscop-van KempenDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Anne Boerema-de MunckDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Wilfred F J van IJckenCenter for Biomics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Rene M H WijnenDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Marco SchnaterDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Robbert J RottierDepartment of Paediatric Surgery, Erasmus University Medical Centre, Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. r.rottier@erasmusmc.nl.

Funding

Stichting Vrienden van het Sophia S22-38
6 · The paper itself

Abstract

backgroundCongenital Pulmonary Airway malformations (CPAM) may lead to malignant degeneration, and therefore many surgeons opt to resect CPAM even in asymptomatic patients. Previously, we identified Kirsten rat sarcoma virus (KRAS) mutations in a subset of CPAM patients, possibly indicating a pre-malignant state. In order to unify treatment strategy in (asymptomatic) patients we focused on KRAS mutations as a potential risk factor for developing malignancy in CPAM.

methodsResected lung tissue of CPAM patients was separated in affected region ("cyst") and non-affected region ("control") to subsequently initiate airway organoids. Cyst and control organoids from the same patients with and without KRAS mutations (KRAS

resultsScRNA-Seq data revealed differences in cell proportions between KRAS

conclusionsKRAS

Indexed as

Cystic Adenomatoid Malformation of Lung, CongenitalLung NeoplasmsMutationPrecancerous ConditionsProto-Oncogene Proteins p21(ras)FemaleHumansMaleKRAS protein, humanProto-Oncogene Proteins p21(ras)Congenital pulmonary airway malformationsKRASMutationsOrganoids

Identifiers

PMID41540433
PMCPMC12892516

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.