Evidence map›Paper›PMID 41540704›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[ERI3 expression is elevated in hepatocellular carcinoma and correlates with poor patient prognosis].

Xinli Zhao, Haojie Wang, Yinchun Song, Shuai Yuan, Zhen Zhang, Xingqi Zhou, Shanshan Li, Xian Li, Feng Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xinli ZhaoSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Haojie WangSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Yinchun SongSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Shuai YuanSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Zhen ZhangSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Xingqi ZhouSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Shanshan LiSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Xian LiSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.
Feng LiSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze the expression pattern of Exoribonuclease Family Member 3 (ERI3) in hepatocellular carcinoma (HCC) tissues and its influences on long-term prognosis and cancer cell metastasis.

methodsBased on the TCGA-LIHC dataset (including 377 HCC and 50 adjacent normal tissues), the differential expression of ERI3 was analyzed using DESeq2, and the results were validated using immunohistochemical data from the HPA database. A protein-protein interaction network was constructed using STRING and GeneMANIA. The prognostic value of ERI3 was assessed by Cox regression and Kaplan-Meier (KM) survival analyses, its diagnostic efficacy evaluated by ROC curve analysis, and its correlation with immune infiltration analyzed with ssGSEA algorithm. A nomogram prognostic model was established using multivariate Cox regression. For functional validation of ERI3

resultsERI3 was significantly overexpressed in HCC tissues (

conclusionsERI3 overexpression promotes HCC cell proliferation, migration, and invasion and is strongly linked to a poor prognosis of the patients.

Indexed as

Carcinoma, HepatocellularExoribonucleasesLiver NeoplasmsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMalePrognosisBiomarkers, TumorExoribonucleasesERI3hepatocellular carcinomametastasisprognosis

Identifiers

PMID41540704
PMCPMC12809041

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.