Evidence map›Paper›PMID 41540705›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Overexpression of lncRNA SNHG12 promotes docetaxel resistance of prostate cancer cells by activating PI3K/AKT signaling

Cheng Zhao, Wen Li, Baoshou Zheng, Guangming Wang, Zhisong Xiao, Yunpeng Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng ZhaoDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.
Wen LiDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.
Baoshou ZhengDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.
Guangming WangDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.
Zhisong XiaoDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.
Yunpeng LiDepartment of Urology, First Affiliated Hospital of Dali University, Dali 671000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the regulatory role of lncRNA SNHG12 in docetaxel (DTX) resistance of prostate cancer (PCa) cells.

methodsTumor-bearing male BALB/c nude mouse models were stablished by dorsal subcutaneous injection of PC-3 cells or DTX-resistant PC-3 (PC-3R) cells, either with or without transfection with sh-SNHG12 prior to the injection (

resultsSNHG12 expression was significantly up-regulated in PC-3R cells. SNHG12 knockdown effectively inhibited proliferation and migration of PC-3R cells

conclusionsSNHG12 knockdown inhibits DTX resistance of PCa cells by reducing SNHG12 binding to ELAVL1 to inhibit the activation the PI3K/AKT signaling pathway.

Indexed as

Drug Resistance, NeoplasmELAV-Like Protein 1Prostatic NeoplasmsRNA, Long NoncodingAnimalsCell Line, TumorCell MovementCell ProliferationDocetaxelGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudePC-3 CellsDocetaxelELAVL1 protein, humanELAV-Like Protein 1Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long NoncodingSNHG12 long non-coding RNA, humanTaxoidsdocetaxeldrug resistanceELAVL1lncRNA SNHG12PI3K / AKT signaling pathwayprostate cancer

Identifiers

PMID41540705
PMCPMC12809035

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.