ArticleACS applied materials & interfaces2026
IL-4/Nanohydroxyapatite Codelivery in a Dual-Bionic Scaffold: Design and Immunomodulatory Endogenous Osteogenesis Mechanism.
Feng-Ze Wang, Yao Yu, Hui-Yuh Soh, Shuo Liu, Lei-Hao Hu, Zu-Nan Tang, Wen-Bo Zhang, Xin Peng
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In one paragraphArticle in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Feng-Ze WangDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Yao YuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Hui-Yuh SohDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, University Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Shuo LiuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Lei-Hao HuDepartment of General Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Zu-Nan TangDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Wen-Bo ZhangDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.
Xin PengDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, P. R. China.ORCID 0000-0001-8535-1771 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Large-scale repairs of bone defects face the challenges of a dynamic extracellular matrix (ECM) signaling deficiency and mismatched hard-tissue biomimicry. This study addressed the limited bioactivity and insufficient endogenous osteogenic capacity of current 3D-printed polycaprolactone/nanohydroxyapatite (PCL/nHA) scaffolds by designing a dual-bionic PCL/nHA scaffold that integrated "soft" ECM signaling with "hard" structural support. The soft hydrogel-based ECM mimicry of the scaffold enabled time-programmed interleukin-4 (IL-4) release to drive macrophage M2 polarization and subsequent anti-inflammatory cytokine (IL-10, TGF-β) secretion, thereby initiating a cascade that enhanced osteogenesis. Structurally, the gyroid architecture of the scaffold replicated natural bone microchannels, while sustained nHA hydrolysis released Ca
Indexed as
DurapatiteInterleukin-4OsteogenesisTissue ScaffoldsAnimalsBone RegenerationCell DifferentiationHydrogelsMacrophagesMiceNanostructuresPolyestersPrinting, Three-DimensionalRAW 264.7 CellsTransforming Growth Factor betaDurapatiteHydrogelsInterleukin-4polycaprolactonePolyestersTransforming Growth Factor beta3D printingbionic scaffoldbone formationhydrogelmacrophage
Identifiers
PMID41540958
PMCPMC12862770
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