ArticleiScience2026
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Regulated Cell Death in Calcium Oxalate Stone Disease: From Tubular Epithelial Injury to Inflammatory Amplification.Journal of inflammation research · 2026Review
- The Application of Nanomaterials in Kidney Stone Disease: Emerging Strategies for Early Diagnosis, Targeted Therapy, and Prevention.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article explored the differences in pyroptosis mediated by calcium oxalate monohydrate (COM) crystals with sizes of 100 nm, 1 μm, 3 μm, 5 μm, and 10 μm and were used to induce pyroptosis of HK-2 cells. The proportion of pyroptosis cells was detected by caspase-1/PI double staining. Three small-sized COM crystals (0.1-3 μm) could be endocytosis by HK-2 cells and increased intracellular oxidative stress, which further promoted the activation of NLRP3 inflammasome and pyroptosis. The two COM crystals with large sizes (3-10 μm) were difficult to endocytose, and the main mechanism was the crystal adhesion, leading to pyroptosis. Crystal endocytosis leads to higher pyroptosis. The pyroptosis rates mediated by COM with different sizes were as follows: COM-100nm (17.81%) > COM-1μm (17.28%) > COM-3μm (17.25%) > COM-5μm (12.44%) > COM-10μm (9.05%). The smaller the COM crystal size, the higher the pyroptosis rate, which is related to the stronger oxidative stress.
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Registered trials
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