ArticleCureus2025
Severe Anti-CV2/CRMP5, Anti-Hu, and Anti-SOX1 Antibody-Positive Paraneoplastic Neurological Syndrome Associated With Tumor Recurrence During Atezolizumab Therapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a case of an 80-year-old man with small-cell lung cancer who developed paraneoplastic neurological syndrome (PNS) after four years of immune checkpoint inhibitor (ICI) therapy (atezolizumab). The patient presented with bilateral optic neuropathy, parkinsonism, and truncal ataxia. MRI revealed lesions in the basal ganglia and medial temporal lobes. Serological testing revealed a marked elevation of tumor markers, along with the presence of anti-CV2/CRMP5, anti-Hu, and anti-SOX1 antibodies. PNS onset may be primarily triggered by tumor recurrence, with long-term ICI exposure further amplifying the underlying immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.