Evidence map›Paper›PMID 41542042›Full record

ArticleResearch square2026

Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.

Ghamdan Al-Eryani, Sophie Van Der Leij, Etienne Masle-Farquhar, Chia-Ling Chan, Kate Harvey, Sunny Z Wu, Dan Roden, Taopeng Wang, John Reeves, Bertrand Z Yeung and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ghamdan Al-EryaniBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID https://orcid.org/0000-0002-1137-1726
Sophie Van Der LeijCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0009-0008-4349-2806
Etienne Masle-FarquharSt Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.ORCID https://orcid.org/0000-0001-9355-8027
Chia-Ling ChanCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Kate HarveyCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0000-0002-2155-5203
Sunny Z WuCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0000-0002-6153-0449
Dan RodenCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Taopeng WangCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
John ReevesCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Bertrand Z YeungBiolegend, San Diego, CA, USA.
Christopher C GoodnowCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Cindy S MaCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Charles M PerouLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID https://orcid.org/0000-0002-2349-2656
Aziz M Al'KhafajiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID https://orcid.org/0000-0002-4677-5667
Mats NilssonScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 65 Solna, Sweden.ORCID https://orcid.org/0000-0001-9985-0387
Joakim LundebergScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden.ORCID https://orcid.org/0000-0003-4313-1601
Marcel BattenCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Simon JunankarCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Alexander SwarbrickCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.ORCID https://orcid.org/0000-0002-3051-5676

Funding

Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN CARLISLE CALHOUN · 1992 to 2026
$59.3M
NCI NIH HHS P50 CA058223
6 · The paper itself

Abstract

While cancer immunotherapies have primarily focused on activation of cytotoxic CD8 cells, CD4 T cell activity is also associated with survival and immunotherapeutic response in numerous cancers. We applied integrated single-cell RNA sequencing and multiplexed protein epitope profiling to breast cancer samples to resolve the complexity of immune cell states within the tumor microenvironment. This approach enhanced phenotypic resolution, identifying three distinct states within the CD4 T follicular helper-like (Tfh) cell cluster. A CXCR4

Identifiers

PMID41542042
PMCPMC12803361

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.