Evidence map›Paper›PMID 41542129›Full record

ArticleCJC open2025

Association Between Markers of Atrial Cardiopathy and Cognitive Impairment Risk Among Adults with No Suggestive History of Atrial Fibrillation.

Zhe Li, Danielle Marion, Jessica Blair, Elsayed Z Soliman, David Gladstone, Hooman Kamel, David Birnie, Doug Manuel, Frederick W Unverzagt, Virginia J Howard and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhe LiPopulation Outcomes Research Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Danielle MarionPopulation Outcomes Research Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Jessica BlairSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Elsayed Z SolimanEpidemiological Cardiology Centre, Section on Cardiovascular Medicine, Department of Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
David GladstoneICES Central, Toronto, Ontario, Canada.
Hooman KamelDepartment of Neurology, Weill Cornell Medicine, New York, New York, USA.
David BirniePopulation Outcomes Research Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Doug ManuelDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Frederick W UnverzagtSchool of Medicine, Indiana University, Indianapolis, Indiana, USA.
Virginia J HowardSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jodi D EdwardsPopulation Outcomes Research Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Background: Clinical atrial fibrillation (AF) is often preceded by substantive structural and electrical remodelling, termed atrial cardiopathy. This cohort study aims to investigate associations between markers of atrial cardiopathy and the risk of cognitive impairment among aging adults without a suggestive history or documentation of AF. Methods: This analysis included 21,856 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study who were free of AF and cognitive impairment (2003-2007). Markers of atrial cardiopathy included atrial premature complexes (APCs) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Cognitive status was measured using the 6-item screener. Cox proportional hazards regression was used to examine the association between markers of atrial cardiopathy and risk of cognitive impairment (primary outcome) and stroke during the follow-up period (secondary outcomes), separately. Results: During a mean follow-up of 9.9 years, 6058 participants had incident cognitive impairment, and 876 had a stroke. APCs increased the hazard of cognitive impairment by 8% (hazard ratio [HR], 1.08, 95% confidence interval [CI]: 1.01-1.15) and stroke by 10% (HR, 1.10, 95% CI: 1.04-1.17). The highest NTpro-BNP-level quintile ( > 235.2 pg/mL) increased the hazard of cognitive impairment by 53% (HR, 1.53, 95% CI: 1.36-1.72) and stroke by 54% (HR, 1.54, 95% CI: 1.39-1.71). Conclusions: Markers of left atrial cardiopathy, including presence of APCs and a high level of NT-proBNP, may be associated with an increased risk of cognitive impairment and stroke with no suggestive history or documentation of AF.

Indexed as

Atrial cardiopathyatrial fibrillationbiomarkercognitive impairment

Identifiers

PMID41542129
PMCPMC12800839

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.