Evidence map›Paper›PMID 41542439›Full record

ArticlebioRxiv : the preprint server for biology2026

Ongoing lymphoid HIV production drives pyroptosis and GLP-1 counter-regulation in ART-suppressed infection.

Peter A Crawford, Joshua Rhein, Jeffrey G Chipman, Gregory J Beilman, Ross Cromarty, Kevin Escandón, Jodi Anderson, Garritt Wieking, Andrew Johnston, Afeefa Ahmed and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Peter A CrawfordDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8597-4426
Joshua RheinDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-0480-9646
Jeffrey G ChipmanDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Gregory J BeilmanDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Ross CromartyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Kevin EscandónDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7173-7486
Jodi AndersonDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Garritt WiekingDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Andrew JohnstonDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Afeefa AhmedDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Jarrett ReichelDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Alexander KhorutsDivision of Gastroenterology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Christopher M BastingDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Nataliia KuchmaDivision of Gastroenterology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Jason V BakerDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Nichole R KlattDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Ashley T HaaseDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Timothy W SchackerDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2451-9937

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$7.7M
Dietary fat-activated colonocyte-macrophage ketone shuttle drives intestinal inflammationR01AI177584 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$2.9M
HIV Reservoir Dynamics Associated with Metabolic Complications of HIV InfectionR01DK143536 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$1.8M
NCATS NIH HHS UM1 TR004405NIAID NIH HHS R01 AI147912NIAID NIH HHS R01 AI177584NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R01 DK143536
6 · The paper itself

Abstract

Despite effective antiretroviral therapy (ART), many people with HIV (PWH) exhibit persistent immune activation (IA) and suffer metabolic comorbidities. We investigated whether residual HIV production in lymphoid tissues drives IA. Among 20 ART-suppressed PWH, HIV RNA

Indexed as

GLP-1HIVMetabolismPyroptosis

Identifiers

PMID41542439
PMCPMC12803172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.