Evidence map›Paper›PMID 41542521›Full record

ArticlebioRxiv : the preprint server for biology2026

Atomic Layering Thermostable Antigen and Adjuvant (ALTA

Keith A Strand, Heather D'Angelo, Ashley M Gerwing, Isabella R Walters, Emma M Snyder, Alyssa M Ritter, Emily Hite, Yalini H Wijesundara, Annie B Caplan, Daria L Ivanova and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Keith A StrandVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0000-0002-3192-8712
Heather D'AngeloVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0000-0002-6618-9761
Ashley M GerwingVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Isabella R WaltersVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0009-0009-3436-7920
Emma M SnyderVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Alyssa M RitterVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0009-0004-3488-1093
Emily HiteVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Yalini H WijesundaraVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0000-0002-4843-3687
Annie B CaplanVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Daria L IvanovaVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Isabella AllenVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Yu HanVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Lorena R AntunezVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Antu K DeyVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0000-0001-7438-9379
Bryan L SteadmanVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.
Sky W BrubakerVitriVax, Inc., 5500 Central Avenue, Boulder, Colorado, 80301, USA.ORCID 0000-0003-1488-6079

Funding

Adoptive Macrophage Transfers for Nanoparticle DeliveryR35GM147455 · NIGMS · UNIVERSITY OF COLORADO · PI Charles Wyatt Shields IV · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147455
6 · The paper itself

Abstract

Prophylactic vaccines are commonly delivered using a multi-dose regimen with the goal of generating potent, durable protection against a specific pathogen. However, the requirement for multiple administrations can impede patient adherence and reduce overall protection. Designing a single-shot vaccine without compromising efficacy could significantly improve vaccine adherence and performance. Previously, it has been shown that atomic-layer deposition (ALD) of alumina (Al

Indexed as

ALTA®antibody responseHIV-1 vaccinemicroparticlesN332-GT5 gp140sustained releasethermostabilityVaccines

Identifiers

PMID41542521
PMCPMC12803066

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.