Evidence map›Paper›PMID 41542542›Full record

ArticlebioRxiv : the preprint server for biology2026

A Closed Computational-Experimental Loop Identifies Metabolic Collapse at the Root of Macrophage Dysfunction due to Zinc Dyshomeostasis.

Sunayana Malla, Deandra R Smith, Ashley M Peer, Derrick R Samuelson, Daren L Knoell, Rajib Saha

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sunayana MallaDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, NE.
Deandra R SmithDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE.
Ashley M PeerPulmonary Division, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE.
Derrick R SamuelsonPulmonary Division, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE.
Daren L KnoellDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE.
Rajib SahaDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, NE.ORCID 0000-0002-2974-0243

Funding

A Predictive Modeling Framework to Dissect the Dynamic Immunometabolic Responses to Pathogenic infection and the Kinetic Reprogramming of Metabolism in Cancer Cell SystemR35GM143009 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI SAHA, RAJIB · 2021 to 2025
$1.8M
Defective Zn Homeostasis impairs host defense against pneumococcal pneumoniaR01HL156952 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KNOELL, DAREN LEE · 2022 to 2025
$1.5M
NHLBI NIH HHS R01 HL156952NIGMS NIH HHS R35 GM143009
6 · The paper itself

Abstract

Zinc plays a crucial role in immune regulation, the oxidative stress response, and epithelial barrier integrity, yet zinc's precise role in regulating metabolic and immunological functions in myeloid cells remains poorly understood. Here, we employ a systems biology approach using constraint-based modeling to elucidate the consequences of myeloid-specific loss of ZIP8 on macrophage metabolic function and antibacterial capabilities. We demonstrate that macrophage populations in the lung of ZIP8 knockout (

Identifiers

PMID41542542
PMCPMC12803191

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.