Evidence map›Paper›PMID 41542628›Full record

ArticlebioRxiv : the preprint server for biology2026

Murine Neutrophil Chemotaxis Following Burn Injury with Poloxamer 188 Treatment in a Microfluidic Platform.

Hossein Razmi Bagtash, Nagham Alatrash, Udaya Sree Datla, Bhaskar Vundurthy, Shuai Shao, Roopa Koduri, Mecca Islam, Kevin Mutore, Emma Salari, Renqing Wu and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hossein Razmi BagtashDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Nagham AlatrashDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Udaya Sree DatlaDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Bhaskar VundurthyRobotics Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Shuai ShaoDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Roopa KoduriDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Mecca IslamDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Kevin MutoreDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Emma SalariDepartment of Biology, University of Texas at Dallas, Richardson, TX 75080, USA.
Renqing WuDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Vanessa NomelliniDivision of Burn, Trauma, Acute, and Critical Care Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Caroline N JonesDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.

Funding

Utilizing Immune Phenotypes to Prevent Chronic Critical IllnessR35GM138020 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI NOMELLINI, VANESSA · 2020 to 2024
$2.0M
Microsystems to Decipher Leukocyte Decision-MakingR35GM133610 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JONES, CAROLINE N. · 2019 to 2023
$1.8M
NIGMS NIH HHS R35 GM133610NIGMS NIH HHS R35 GM138020
6 · The paper itself

Abstract

This study investigates the effects of Poloxamer 188 (P188) on neutrophil chemotaxis following burn injury in male and female mice using a microfluidic system. Utilizing male and female CD1 mice, we evaluated neutrophil migration towards two chemoattractants, N-formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP) and Leukotriene B4 (LTB4), and FPR1 and BLT1 G protein-coupled receptors after administering P188. Our findings revealed that P188 significantly increased the migration toward LTB4 in both sexes. Additionally, our findings highlight the upregulation of BLT1 and FPR1 markers due to burn injury in both female and male mice in the Burn vs. Sham groups. These results demonstrate the potential of P188 in modulating neutrophil behavior post-burn injury in therapeutic strategies for inflammation management. This microfluidic platform offers a precise and controlled microenvironment for studying neutrophil chemotaxis post-burn injury with and without P188 treatment.

Indexed as

burn injurymicrofluidic systemneutrophil chemotaxisPoloxamer 188 (P188)

Identifiers

PMID41542628
PMCPMC12803259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.