Evidence map›Paper›PMID 41542923›Full record

ArticleFEBS open bio2026

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress-induced cellular senescence.

Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kanoko YoshidaLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Kazuya KusamaLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0002-9120-0475
Ayaka HoriuchiLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Yu KawaguchiLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Atsuya TsuruLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Mikihiro YoshieLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Kazuhiro TamuraLaboratory of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0003-3351-895X

Funding

Japan Society for the Promotion of Science JP23K18345Japan Society for the Promotion of Science JP23KJ1958Japan Society for the Promotion of Science JP24K01913
6 · The paper itself

Abstract

Trophoblast syncytialization is essential for placental function, and its dysregulation contributes to hypertensive disorders of pregnancy (HDPs), which compromise maternal and fetal health. Reduced expression of mitochondrial dihydroorotate dehydrogenase (DHODH) was observed in early-onset HDP placentas in our previous study. Experiments using human trophoblast stem cells demonstrated that DHODH inhibition impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in HDPs. Mitochondrial activators quercetin and riboflavin partially reversed these effects. Our findings suggest that DHODH may be a key regulator of trophoblast differentiation by linking organelle stress to cellular senescence.

Indexed as

Cellular SenescenceDihydroorotate DehydrogenaseOxidoreductases Acting on CH-CH Group DonorsTrophoblastsCell DifferentiationEndoplasmic Reticulum StressFemaleHumansMitochondriaPlacentaPregnancyQuercetinDihydroorotate DehydrogenaseOxidoreductases Acting on CH-CH Group DonorsQuercetincellular senescencedihydroorotate dehydrogenasehuman trophoblast stem cellsHypertensive disorder of pregnancymitochondrial dysfunctionsyncytialization

Identifiers

PMID41542923
PMCPMC13238865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.