Evidence map›Paper›PMID 41543444›Full record

ReviewPhysiological reviews2026

The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.

Andreas A Boehmer, Sandro Ninni, Jordi Heijman, Dobromir Dobrev, Stanley Nattel

Abstract readReview
In one paragraph

Review in Physiological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andreas A BoehmerDepartment of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.ORCID 0000-0002-2306-1370
Sandro NinniINSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Université de Lille, Lille, France.
Jordi HeijmanDivision of Medical Physics & Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Dobromir DobrevDepartment of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
Stanley NattelDepartment of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.ORCID 0000-0002-5565-3311

Funding

The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Resolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9M
Cardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
FKBP5 AND CARDIAC ARRHYTHMOGENESISR01HL164838 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2024 to 2026
$1.7M
Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic RemodelingR01HL176651 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2025 to 2026
$1.1M
Canadian Institutes of Health Research (CIHR) 478053Deutsche Forschungsgemeinschaft (DFG) 517043330European Commission (EC) 965286Heart and Stroke Foundation of Canada (HSF) 22-0031958Heart and Stroke Foundation of Canada (HSF) 23-0035141HHS | National Institutes of Health (NIH) R01HL131517HHS | National Institutes of Health (NIH) R01HL136389HHS | National Institutes of Health (NIH) R01HL160992HHS | National Institutes of Health (NIH) R01HL163277HHS | National Institutes of Health (NIH) R01HL164838HHS | National Institutes of Health (NIH) R01HL165704HHS | National Institutes of Health (NIH) R01HL176651NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL163277NHLBI NIH HHS R01 HL164838NHLBI NIH HHS R01 HL165704NHLBI NIH HHS R01 HL176651
6 · The paper itself

Abstract

Atrial fibrillation (AF) is a major public health problem, associated with increased risks of heart failure, stroke, dementia, and mortality. The treatment of AF involves multiple potential approaches, all of which presently have significant limitations. Over the past 20 years, tremendous advances have been made in understanding the pathophysiological determinants of AF. The present narrative review article aims to address selected issues that are highly relevant to clinically important questions in AF pathophysiology by reviewing insights from both experimental observations and complementary clinical investigations. Issues that we address include

Indexed as

Atrial FibrillationHeart AtriaAnimalsHeart FailureHumansatrial fibrillationcalcium handlinginflammationreentrant arrhythmia mechanismstriggered activity

Identifiers

PMID41543444
PMCPMC12932262

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.