Trial reportUrolithiasis2026
The effect of intrarenal pressure on Stone-Free rates in a pilot study: is there a desired range?
Trial report in Urolithiasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
High intrarenal pressure (IRP) during retrograde intrarenal surgery (RIRS) is associated with postoperative complications such as sepsis. While lowering IRP by the use of ureteral access sheaths (UAS) with or without suction can reduce postoperative complications, data about the impact on stone-free rates (SFR) is limited. Our aim was to evaluate in a pilot study how variations in IRP correlate with SFR. Patients from March 1 and October 31, 2025 with a single renal stone ≥ 1 cm or multiple stones who were randomized to RIRS with a standard or suctioning UAS. Continuous IRP monitoring was performed using the LithoVue™ Elite Single-Use Digital Flexible Ureteroscope System, with the operating surgeon blinded to the recorded values. Receiver Operating Characteristic (ROC) analyses, logistic regressions and Least Absolute Shrinkage and Selection Operator (LASSO) model were used to identify the most informative IRP metrics associated with achieving absolute SFR, defined as zero residual fragments on postoperative computed tomography scan. 20 patients underwent RIRS with a median stone burden of 12 mm (IQR 12–18). The mean average IRP was 20.4 mmHg (SD 13.1). The mean proportions of treatment time with IRP > 20 mmHg, > 40 mmHg, and > 60 mmHg were 52% (SD 23), 16% (SD 17), and 7% (SD 12) respectively, and absolute SFR was 69%. The proportion of treatment time with IRP > 20 mmHg was the most discriminative metric to predict absolute SFR (AUC = 0.821, p = 0.028) with the strongest association based on logistic regression (OR = 1.074, p = 0.033) and LASSO modeling. Optimal thresholds to predict absolute SFR were at least 48% of treatment time > 20 mmHg and average IRP of at least 16 mmHg. Proportion of treatment time with IRP greater than 40 or 60 mmHg did not confer better SFR. The use of suctioning UAS did not influence the effect of IRP on SFR. This pilot study demonstrated that excessively low IRP during RIRS with UAS may compromise procedural efficiency. The relative proportion of operative time with IRP > 20 mmHg, but not > 40 or > 60 mmHg, is an exploratory example for a metric associated with SFR. Further studies are needed to validate our results and define the optimal IRP.
Indexed as
Identifiers
41543577What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.