Evidence map›Paper›PMID 41543628›Full record

ArticleMolecular neurobiology2026

Neuronal Sik1 in the Hypothalamic Paraventricular Nucleus Decreases Blood pressure Elevation Following a High-Salt Diet.

Wei Zhang, Ping Wang, Shuya Qi, Na Huang, Qingyun Huang, Zhongxin Guo, Weifeng Wu, Guohe Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Zhang *Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Ping Wang *Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Shuya Qi *Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Na HuangInstitute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Qingyun HuangInstitute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Zhongxin GuoInstitute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China.
Weifeng WuDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. wucna65@163.com.
Guohe TanInstitute of Neuroscience and Guangxi Key Laboratory of Brain Science, Department of Human Anatomy, School of Basic Medical Sciences, Guangxi Medical University, 22 Shuang-Yong Road, Nanning, Guangxi, 530021, People's Republic of China. tanguohe@gxmu.edu.cn.

Funding

National Natural Science Foundation of China 81571268Natural Science Foundation of Guangxi Zhuang Autonomous Region 2023GXNSFDA026002
6 · The paper itself

Abstract

Blood pressure (BP) regulation involves complex interactions between peripheral organs and the brain. As a key area gating BP regulation, how the hypothalamic paraventricular nucleus (PVN) modulates salt‑sensitive hypertension remains unclear. Here, we found that Sik1, a member of the AMP-activated protein kinase family, was upregulated in PVN neurons of mice following a high-salt diet (HSD). When Sik1 was ablated, Sik1 knockout mice exhibited an increase in BP upon HSD feeding. Furthermore, specific deletion of the Sik1 gene in the nervous system by Nestin-Cre (Nestin-Cre;Sik1

Indexed as

Blood PressureNeuronsParaventricular Hypothalamic NucleusProtein Serine-Threonine KinasesSodium Chloride, DietaryAnimalsArginine VasopressinMaleMice, Inbred C57BLMice, KnockoutMicrogliaNF-kappa BSignal TransductionArginine VasopressinNF-kappa BProtein Serine-Threonine KinasesSik1 protein, mouseSodium Chloride, DietaryBlood pressureHigh-salt dietParaventricular nucleusSik1

Identifiers

PMID41543628
PMCPMC12811292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.