Evidence map›Paper›PMID 41543777›Full record

ArticleMikrochimica acta2026

A one-for-four redox probe strategy for multiplex electrochemical POCT of thrombotic biomarkers.

Minghui Cai, Wenwen Zhang, Haixu Yao, Huiyu Su, Yang Cao, Jiaxin Li, Xinyu Min, Feiyun Cui, Hui Zhu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minghui Cai *Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wenwen Zhang *Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Haixu YaoDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Huiyu SuDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang CaoCenter of Functional Experiment, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jiaxin LiCenter of Functional Experiment, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Xinyu MinDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Feiyun CuiDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China. feiyun@hrbmu.edu.cn.
Hui ZhuDepartment of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China. zhuhui@ems.hrbmu.edu.cn.

Funding

China Postdoctoral Science Foundation General Project 2025M772552Funding Program for Preferential Returned Scholars of Heilongjiang Province 21032240006National Key R&D Program from Ministry of Science and Technology of China 2023YFE 0113500Natural Science Foundation of Heilongjiang Province JJ2024YX0560"Spring Goose" Talent Team Support Program of Heilongjiang Province 2022CY CX0202the Scientific Research Fund of Heilongjiang Provincial Scientific Research Institutes CZKYF2023-1-A011Young Elite Scientist Sponsorship Program of Heilongjiang Province 20240NTJ 018
6 · The paper itself

Abstract

Thrombotic diseases remain a major global health concern with high morbidity and mortality. Four biomarkers (TAT, t-PAIC, TM, PIC) enable real-time monitoring of coagulation, addressing limitations of traditional diagnostics. Herein, we developed a multiplex electrochemical immunosensor for the simultaneous detection of these biomarkers. The sensing platform is constructed on a glassy carbon electrode modified with gold nanoparticles and laser-induced graphene (AuNPs-LIG), which enhances conductivity and signal output. A "One-for-Four" strategy was employed using four distinct redox probes (AQ, OAP, MB, PPD), each conjugated to a specific antibody via amidation and anchored to functionalized carbon nanotubes (Au@CNTs), forming a multichannel signal amplification system with high sensitivity. The immunosensor exhibited excellent linearity (10-100 ng/mL, R

Indexed as

Biosensing TechniquesElectrochemical TechniquesThrombosisAntibodies, ImmobilizedBiomarkersElectrodesGoldGraphiteHumansImmunoassayLimit of DetectionMetal NanoparticlesNanotubes, CarbonOxidation-ReductionRapid Diagnostic TestsAntibodies, ImmobilizedBiomarkersGoldGraphiteNanotubes, CarbonAu nanoparticle modified glassy carbon electrodeDifferential pulse voltammetryFunctionalized carbon nanotubeLaser-induced grapheneRedox probeSimultaneous multi-analyte immunoassayThrombotic biomarkers

Identifiers

PMID41543777

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.