Evidence map›Paper›PMID 41543992›Full record

ArticleJournal of vascular research2026

Differential Blood-Brain Barrier Permeability Driven by Asymmetric Hypoperfusion in a Vascular Dementia Model.

Mengjun Dai, Kuizhi Qu, Ying Jiang, Song Gao, Yan-Ning Rui, Zhen Xu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengjun DaiDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kuizhi QuDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ying JiangDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Song GaoDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yan-Ning RuiDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA, yanning.rui@uth.tmc.edu.
Zhen XuDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA, zhen.xu@uth.tmc.edu.

Funding

The Role of Podosomes in Cerebrovascular Integrity and Intracranial AneurysmR01NS126664 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhen Xu · 2023 to 2026
$1.5M
Role of Selective Autophagy of Focal Adhesion in Intracranial AneurysmR01NS126820 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Yanning Rui · 2023 to 2026
$1.5M
NINDS NIH HHS R01 NS126664NINDS NIH HHS R01 NS126820
6 · The paper itself

Abstract

introductionBlood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aimed to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.

methodsAsymmetric bilateral common carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG, and albumin extravasation. A modified tissue processing protocol optimized endogenous marker detection. Regional and sex-based differences in BBB permeability were analyzed.

resultsIncreased BBB permeability was observed in both corpus callosum and cortical areas, with significantly more severe leakage in the left cortex compared to the right, correlating directly with lower cerebral blood flow on the left side. In contrast, no significant asymmetrical difference in BBB permeability was detected in the corpus callosum. Additionally, male and female mice exhibited similar patterns of BBB permeability.

conclusionThis study provides the first evidence that asymmetrical hypoperfusion significantly impacts regional BBB permeability in a mouse model of VaD. These findings highlight the importance of local hemodynamic changes in driving BBB dysfunction and underscore potential therapeutic targets for preventing or mitigating VaD progression.

Indexed as

Blood-Brain BarrierCapillary PermeabilityCarotid StenosisCerebrovascular CirculationDementia, VascularAnimalsCerebral CortexCorpus CallosumDisease Models, AnimalEvans BlueFemaleMaleMiceMice, Inbred C57BLSex FactorsEvans BlueAssymetric bilateral common carotid artery stenosisBlood-brain barrierEndogenous markersEvans blueVascular dementia

Identifiers

PMID41543992
PMCPMC13023342

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.