ArticlePloS one2026
Gamma irradiation crosslinked fluorescent nanocarbon based biodegradable hydrogel for controlled release of antibiotics.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Controlled and sustained antibiotic delivery is critical for combating antimicrobial resistance while minimizing side effects. Herein, a novel biodegradable hydrogel system, synthesized via gamma irradiation, incorporating fluorescent carbon dots (CDs) as multifunctional nano-crosslinkers, has been reported. The CDs, prepared from sustainable bio-precursors, reinforced the polymer network and enhanced the mechanical stability and swelling behavior, while simultaneously serving as intrinsic fluorescent probes for potential real-time monitoring of degradation and drug release. Thorough characterization revealed consistent morphology, adjustable biodegradability, and enhanced rheological characteristics. Drug release investigations demonstrated a diffusion-controlled mechanism, wherein the integration of CD diminished the cumulative antibiotic release from approximately 70% to approximately 40%, thereby facilitating precise regulation of release kinetics. The single-step gamma irradiation method facilitates concurrent crosslinking and sterilization, providing an efficient and scalable production strategy. This study presents a multifunctional hydrogel platform that integrates sustainable nanomaterials, regulated drug administration, and real-time monitoring, thereby facilitating the development of advanced theragnostic systems.
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