Evidence map›Paper›PMID 41544163›Full record

ArticleScience advances2026

Remodeling of

Emmanuel Cazottes, Charbel Alfeghaly, Cloé Rognard, Anamaria Necsulea, Agnese Loda, Gaël Castel, Laura Villacorta, Michael Dong, Edith Heard, Irène Aksoy and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Replicable generation and stable maintenance of rhesus macaque iPSCs forFrontiers in cell and developmental biology · 2026
    Article
  2. Review
  3. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emmanuel CazottesUniversité Paris Cité, CNRS UMR7216, Epignetics and Cell Fate, F-75013 Paris, France and Sex Chromosomes, Development and Diseases, CNRS UMR3244, Sorbonne Université.ORCID 0000-0002-9583-2816
Charbel AlfeghalyUniversité Paris Cité, CNRS UMR7216, Epignetics and Cell Fate, F-75013 Paris, France and Sex Chromosomes, Development and Diseases, CNRS UMR3244, Sorbonne Université.
Cloé RognardUniversité Lyon 1, INSERM U1208, Stem Cell and Brain Research Institute (SBRI), F-69500 Bron, France.ORCID 0000-0003-0369-8291
Anamaria NecsuleaUniversité Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France.
Agnese LodaEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Gaël CastelUniversité Paris Cité, CNRS UMR7216, Epignetics and Cell Fate, F-75013 Paris, France and Sex Chromosomes, Development and Diseases, CNRS UMR3244, Sorbonne Université.ORCID 0000-0002-7563-1179
Laura VillacortaEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-9509-8594
Michael DongDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden.ORCID 0000-0003-4084-3099
Edith HeardEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-8052-7117
Irène AksoyUniversité Lyon 1, INSERM U1208, Stem Cell and Brain Research Institute (SBRI), F-69500 Bron, France.
Pierre SavatierUniversité Lyon 1, INSERM U1208, Stem Cell and Brain Research Institute (SBRI), F-69500 Bron, France.
Céline MoreyUniversité Paris Cité, CNRS UMR7216, Epignetics and Cell Fate, F-75013 Paris, France and Sex Chromosomes, Development and Diseases, CNRS UMR3244, Sorbonne Université.ORCID 0000-0001-9513-0278
Claire RougeulleUniversité Paris Cité, CNRS UMR7216, Epignetics and Cell Fate, F-75013 Paris, France and Sex Chromosomes, Development and Diseases, CNRS UMR3244, Sorbonne Université.ORCID 0000-0003-3861-4940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unraveling how gene regulations are remodeled during evolution is central to understanding how biological processes evolve. We explored this question in the frame of X-chromosome inactivation, a process under strong selective constraint, governed by the

Indexed as

Biological EvolutionEvolution, MolecularPrimatesRNA, Long NoncodingAnimalsEmbryonic Stem CellsGene Expression RegulationHumansX Chromosome InactivationRNA, Long NoncodingXIST non-coding RNA

Identifiers

PMID41544163
PMCPMC12810636

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.