ArticleCancer cell2026
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
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Article in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Lipidomic analysis of isolated lipid droplets reveals potential metabolic pathway differences between medulloblastoma subgroups.Frontiers in neuroscience · 2026Article
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Authors and funding
85 authors.
Flavia BernardiInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Jacob TorrejonInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Irene BasiliInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France; Istituto Pasteur-Fondazione Cenci Bolognetti, University of Rome La Sapienza, 00161, Rome, Italy.
Randy Van OmmerenDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Véronique MarsaudInstitut Curie, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris-Saclay, Orsay, France.
Hua YuInstitut Curie, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris-Saclay, Orsay, France.
Julie TalbotInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Judith SouphronInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Emilie IndersieInstitut Curie, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris-Saclay, Orsay, France.
Antoine ForgetInstitut Curie, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris-Saclay, Orsay, France.
Benjamin BonneauUniversité Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Alexane MassiotInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Coralie AlcazarCentre de Recherches en Cancérologie de Toulouse, Université de Toulouse, Inserm, CNRS, Equipe Labellisée LIGUE 2023, Toulouse, France; Labex TOuCAN, Toulouse, France.
Laurine FigeacInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Emma BonerandiInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Gabriele CancilaInstitut Curie, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris-Saclay, Orsay, France.
Olga SirbuDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Navneesh YadavDepartment of Neurological surgery, University of Pittsburgh School of Medicine, and Cancer biology Program, UPMC Hillman Cancer center, Pittsburgh, PA, USA.
Dinesh MohanakrishnanDepartment of Neurological surgery, University of Pittsburgh School of Medicine, and Cancer biology Program, UPMC Hillman Cancer center, Pittsburgh, PA, USA.
Bérangère LombardInstitut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique, 26 rue d'Ulm, 75248 Paris, France.
Damarys LoewInstitut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique, 26 rue d'Ulm, 75248 Paris, France.
Patrick PoulletInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Stephane LivaInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Marta LovinoDipartimento di Ingegneria Enzo Ferrari, University of Modena and Reggio Emilia, Modena, Italy.
I-Hsuan LinInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Takuma NakashimaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Tarek GharsalliInovarion, Paris, France.
Paul Antoine NicolasInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Naoji YubukiInstitut Curie, PSL University, CNRS UAR2016, INSERM US43, Université Paris-Saclay, Multimodal Imaging Center, 91400 Orsay, France.
Roberto A RibasDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL 32610, USA.
Benoit ColschUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), MetaboHUB, Gif sur Yvette, France.
Emeline Chu-VanUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), MetaboHUB, Gif sur Yvette, France.
Florence CastelliUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), MetaboHUB, Gif sur Yvette, France.
Julio Lopes SampaioInstitut Curie, CurieCoreTech Metabolomics and Lipidomics platform, Paris, France.
Sophie LeboucherInstitut Curie, Histology Facility, Orsay 91400, France.
Charlene LasgiInstitut Curie, Cytometry Platform, Orsay 91400, France.
Laetitia BesseInstitut Curie, PSL University, CNRS UAR2016, INSERM US43, Université Paris-Saclay, Multimodal Imaging Center, 91400 Orsay, France.
Marie-Noëlle SolerInstitut Curie, PSL University, CNRS UAR2016, INSERM US43, Université Paris-Saclay, Multimodal Imaging Center, 91400 Orsay, France.
Valentina Lo ReInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France.
Nathalie PlanqueInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France; Université Paris Cité, France.
Namal AbeysundaraThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Polina BalinDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.
Hao WangThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Haipeng SuDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.
Xiaochong WuDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.
Florence M G CavalliInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Olivier SaulnierINSERM U1330, Genomics and Development of Childhood Cancers Lab, Institut Curie, PSL University, SIREDO Oncology Center, Paris, France.
Elisa FicarraDipartimento di Ingegneria Enzo Ferrari, University of Modena and Reggio Emilia, Modena, Italy.
Lucia Di MarcotullioIstituto Pasteur-Fondazione Cenci Bolognetti, University of Rome La Sapienza, 00161, Rome, Italy; Department of Molecular Medicine, University of Rome La Sapienza, 00161 Rome, Italy.
Kohei KumegawaCancer Cell Diversity Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Reo MaruyamaProject for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Daisuke KawauchiDepartment of Neuro-oncology, Institute of Brain Science, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Daniel PicardDepartment of Pediatric Oncology and Hematology, Saarland University Medical Center, Homburg, Germany.
Marc RemkeDepartment of Pediatric Oncology and Hematology, Saarland University Medical Center, Homburg, Germany.
Laurent RiffaudDepartment of Pediatric Neurosurgery, Rennes University Hospital, Rennes, France.
Chloé PuiseuxDepartment of Pediatric Oncology, Rennes University Hospital, Rennes, France.
Yassine BouchouchaSIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, 75005 Paris, France.
Sophie HuybrechtsDepartment of Pediatric Hemato-Oncology, National Center for Pediatrics, Centre Hospitalier du Luxembourg, Luxembourg City, Luxembourg.
Marie SimbozelDepartment of Child and Adolescents Oncology, Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.
Franck BourdeautSIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, 75005 Paris, France; Institut Curie, INSERM U1330, Children's Oncology Research Unit (CONCERT), Université Paris Cité, Paris, France.
Pascale VarletDepartment of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France; UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Inserm, Paris, France.
Stéphanie PugetDepartment of Pediatric Neurosurgery, Necker Enfants Malades Hospital, APHP, Université Paris Cité, Paris, France.
Thomas BlauwblommeDepartment of Pediatric Neurosurgery, Necker Enfants Malades Hospital, APHP, Université Paris Cité, Paris, France.
Mamy AndrianteranagnaInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Julien Masliah PlanchonUnit of Somatic Genetics, Institut Curie, Paris, France.
Aurelien DugourdHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.
Julio Saez-RodriguezHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridgeshire, UK.
Emmanuel BarillotInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Nicolas ServantInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Loredana MartignettiInstitut Curie, INSERM U1331, MINES ParisTech, PSL Research University, Paris, France.
Jeremy RichHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Marcel KoolHopp Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany; University Medical Center Utrecht (UMCU), Utrecht, the Netherlands.
Stefan M PfisterHopp Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Sameer AgnihotriUniversity of Pittsburgh, Department of Neurological Surgery, Pittsburgh, PA, USA.
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Marjorie FanjulUniversité Toulouse, CNRS, Inserm, CRCT, Equipe labellisée Ligue Contre le Cancer, Toulouse, France.
Won-Jing WangInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jin-Wu TsaiInstitute of Brain Science, Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ramon C SunDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL 32610, USA.
Kévin BeccariaDepartment of Pediatric Neurosurgery, Necker Enfants Malades Hospital, APHP, Université Paris Cité, Paris, France.
Christelle DufourDepartment of Child and Adolescents Oncology, Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France; INSERM U981, Molecular Predictors and New Targets in Oncology, University Paris-Saclay, Villejuif, France.
Jean-Emmanuel SarryCentre de Recherches en Cancérologie de Toulouse, Université de Toulouse, Inserm, CNRS, Equipe Labellisée LIGUE 2023, Toulouse, France; Labex TOuCAN, Toulouse, France. Electronic address: jean-emmanuel.sarry@inserm.fr.
Kulandaimanuvel Antony MichealrajDepartment of Neurological surgery, University of Pittsburgh School of Medicine, and Cancer biology Program, UPMC Hillman Cancer center, Pittsburgh, PA, USA. Electronic address: micheala@pitt.edu.
Michael D TaylorDivision of Neurosurgery, Department of Surgery, Texas Children's Hospital, Houston, TX, USA; Neuro-oncology Research Program, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA. Electronic address: michael.taylor@bcm.edu.
Olivier AyraultInstitut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Paris, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée LIGUE 2024, Orsay, France. Electronic address: olivier.ayrault@curie.fr.
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MMouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4MBrain Glucose Deficiency: Mechanisms and ModulationRM1NS133593 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph J. Pancrazio, Juan M. Pascual · 2023 to 2026
$5.3MCCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastomaR01CA255369 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARZIA, LIVIA, TAYLOR, MICHAEL D. · 2021 to 2025
$3.9MDeciphering the Glycan Code in Human Alzheimer’s Disease BrainR01AG078702 · NIA · UNIVERSITY OF KENTUCKY · PI Peggi M Angel, Sean Curtis Bendall · 2022 to 2026
$3.8MPrevention and treatment of lethal metastases in group 3 medulloblastomaR01NS106155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2018 to 2022
$2.8MAberrant Glycogen in Lung Adenocarcinoma TumorigenesisR01CA266004 · NCI · UNIVERSITY OF KENTUCKY · PI Matthew S. Gentry, Ramon C. Sun · 2022 to 2026
$2.6MAberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's DiseaseR01AG066653 · NIA · UNIVERSITY OF KENTUCKY · PI SUN, RAMON C. · 2020 to 2024
$1.9MTargeting Glycogen Metabolism in Ewing's Sarcoma: Diagnostic, Prognostic, and Therapeutic ApplicationsR01CA288696 · NCI · UNIVERSITY OF FLORIDA · PI Matthew S. Gentry, Ramon C. Sun · 2024 to 2026
$1.8MNCI NIH HHS P30 CA047904NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA255369NCI NIH HHS R01 CA266004NCI NIH HHS R01 CA288696NIA NIH HHS R01 AG066653NIA NIH HHS R01 AG078702NINDS NIH HHS R01 NS106155NINDS NIH HHS RM1 NS133593
Abstract
Medulloblastoma, the most common malignant brain tumor of childhood, exhibits significant biological complexity that demands deeper exploration. Here, we present a large multiomics dataset integrating data from 384 primary medulloblastoma patient samples across five omic layers: CpG methylome, transcriptome, proteome, phosphoproteome, and metabolome, paired with associated clinical metadata. Data integration revealed intertumoral heterogeneity of lipid metabolism across proteomic subtypes. Notably, while the MYC-FASN-SCD axis drives lipid biosynthesis, pathway inhibition elicits a compensatory escape mechanism in vivo through exogenous fatty acid uptake. Unexpectedly, we demonstrated that MYC triggers lipid storage, creating a unique dependency on lipid droplet-mitochondria communications to sustain tumor maintenance in vivo. Together, this comprehensive analysis reveals a targetable vulnerability downstream of MYC that constitutes a promising therapeutic approach to treat currently untreatable medulloblastoma subtypes.
Indexed as
Cerebellar NeoplasmsLipid MetabolismMedulloblastomaAnimalsHumansMiceMultiomicsProteomeProteomicsProto-Oncogene Proteins c-mycTranscriptomeProteomeProto-Oncogene Proteins c-myclipid biosynthesislipid dropletslipid oxidative stressmedulloblastomametabolomicsmultiomics integrationpediatric cancerphosphoproteomicsproteomicstranscriptomics
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