Evidence map›Paper›PMID 41545305›Full record

ArticleJournal for immunotherapy of cancer2026

Stearoyl-CoA desaturase-1 controls the differentiation and antitumoral function of Th9 lymphocytes.

Emma Groetz, Sabrina Perrey, Alvaro Baeza Garcia, Adélie Dumont, Laurent Pichon, Celine Trinh Le Vi Kieu, Léa Pierre, Charles Thomas, Richard Flavell, Emeric Limagne and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emma GroetzUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0009-0009-8114-448X
Sabrina PerreyUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0009-0000-4440-8647
Alvaro Baeza GarciaLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Wilrijk, Belgium.ORCID http://orcid.org/0000-0001-6032-7847
Adélie DumontUniversité Bourgogne Europe, UMR PAM, Institut Agro Dijon, INRAE, Dijon, France.ORCID http://orcid.org/0009-0009-6558-6835
Laurent PichonUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0009-0008-6529-9986
Celine Trinh Le Vi KieuUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0009-0000-9654-0084
Léa PierreUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.
Charles ThomasUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0000-0001-9998-6698
Richard FlavellImmunobiology, Yale School of Medicine, New Haven, Connecticut, USA.ORCID http://orcid.org/0000-0003-4461-0778
Emeric LimagneUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0000-0002-1098-8441
Frederique VegranUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0000-0002-4377-1441
Lionel ApetohMicrobiology and Immunology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID http://orcid.org/0000-0002-2774-438X
Francois GhiringhelliUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France.ORCID http://orcid.org/0000-0002-5465-8305
Mickael RiallandUniversité Bourgogne Europe, INSERM, Center for Translational and Molecular Medicine, Institut Agro Dijon, UMR1231, Dijon, France mickael.rialland@u-bourgogne.fr.ORCID http://orcid.org/0000-0001-9693-9351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStearoyl-CoA desaturase 1 (SCD1) is a key enzyme in fatty acid (FA) metabolism that catalyzes the addition of a cis double bond to palmitic and stearic saturated FAs, producing palmitoleic and oleic monounsaturated FAs, respectively. Interleukin (IL)9-secreting CD4

resultsA specific monounsaturated FA profile is found in Th9 lymphocytes compared with Th1, Th2, Th17 and regulatory T cell (Treg) lymphocyte subsets and is correlated to the induction of SCD1 expression in mouse and human Th9 differentiated in vitro with TGFβ1 and IL4. The expression of SCD1 is also detected in tumor-draining lymph nodes and tumor-infiltrating Th9 lymphocytes of mice. The canonical Smad3 and non-canonical Pi3K members of the TGFβ signaling drive SCD1 expression in combination with IL4 during Th9 polarization. The invalidation of

conclusionWe demonstrate that SCD1 contributes to Th9 differentiation and their antitumoral activity via the regulation of Smad2/3 signaling.

Indexed as

Stearoyl-CoA DesaturaseT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationFemaleHumansMiceSignal TransductionSmad3 ProteinSCD protein, humanSmad3 ProteinStearoyl-CoA DesaturaseAdoptive cell therapy - ACTImmunotherapySolid tumorT-Lymphocytes

Identifiers

PMID41545305
PMCPMC12815060

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.