Evidence map›Paper›PMID 41545356›Full record

ArticleNPJ Parkinson's disease2026

Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson's and inflammatory bowel disease.

MacKenzie L Bolen, Marc Buendia, Ji Shi, Hannah Staley, Jennifer M Kachergus, Philip A Efron, Gwoncheol Park, Ravinder Nagpal, Stephan D Alvarez, Qing-Shan Xue and 7 more

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

MacKenzie L BolenCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-1973-3784
Marc BuendiaUniversity of Barcelona, Gran Via de les Corts, 08007, Barcelona, Spain.
Ji ShiDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Hannah StaleyCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
Jennifer M KachergusDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Philip A EfronDepartment of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA.
Gwoncheol ParkThe Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA.
Ravinder NagpalThe Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA.
Stephan D AlvarezNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Qing-Shan XueCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
Nikolaus R McFarlandNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Ellen M ZimmermannDepartment of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA.
Christopher E ForsmarkDepartment of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA.
Kelly B MeneesCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-4282-8546
Azucena SalasInflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, CIBER-EHD, Barcelona, Spain.
E Aubrey ThompsonDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Malú Gámez TanseyCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu.ORCID http://orcid.org/0000-0002-1719-4708

Funding

R35 Equipment SupplementR35GM140806 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2021 to 2025
$2.2M
Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD riskRF1AG057247 · NIA · UNIVERSITY OF FLORIDA · PI NEISH, ANDREW S, TANSEY, MARIA DE LOURDES GAMEZ · 2017 to 2017
$1.6M
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationR01NS128800 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI STEVEN M FINKBEINER, Maria de Lourdes Gamez Tansey · 2025 to 2026
$1.5M
Aligning Science Across Parkinson's ASAP-020527Michael J. Fox Foundation for Parkinson's Research ASAP-020527Ministerio de Ciencia e Innovación PRE2022-102617NIA NIH HHS RF1 AG057247NIGMS NIH HHS R35 GM140806NIH HHS 5R35GM140806NIH HHS 7RF1AG057247NINDS NIH HHS R01 NS128800Parkinson's Foundation PF-VSA 1293721Parkinson's Foundation Research Center of Excellence Award
6 · The paper itself

Abstract

Parkinson's disease (PD) is the fastest-growing neurodegenerative disease in the world

Identifiers

PMID41545356
PMCPMC12847817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.