ArticleScientific reports2026
Effect of telomere length and related gene polymorphism in signaling pathway on semen quality.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comparative machine learning analysis identifies random forest and adaboost as superior models for the evaluation of semen quality and reproductive hormones.Frontiers in reproductive health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
This study investigates sperm telomere length (STL), gene polymorphisms in telomere-related pathway genes, and semen quality, were detected to evaluate their potential as a biomarkers of semen quality. Associationally, it explores between gene polymorphisms and STL, and semen quality. A total of 1,349 male volunteers from the Pu-yang Reproductive Medicine Center were selected as research subjects. Computer-aided sperm analysis analysis was employed to assess semen parameters. Real-time fluorescence quantitative PCR was utilized to measure STL, while polymerase chain reaction was used to detect gene polymorphisms. The correlation between STL, related gene polymorphisms, and semen parameters was subsequently analyzed. Among the 1,349 subjects, the proportions of semen volume, total sperm count, sperm concentration, progressive motility, and total sperm motility meeting the criteria exceeded 80%, whereas the proportion of normal morphology was only 32.46%. The results of the restricted cubic spline (RCS) analysis indicated that STL exhibtied a nonlinear relationship with sperm concentration (P < 0.001) and total sperm count (P = 0.007). After categorizing STL levels into quartiles, the risk of abnormalities in total sprem count (OR = 0.37[0.15,0.94], P = 0.037), sperm concentration (OR = 0.31[0.11,0.83], P = 0.020), progressive motility (OR = 0.27[0.12,0.61)], P = 0.002), and total vitality percentage (OR = 0.19[0.07,0.51], P = 0.001) was lower in the third quartile when compared to the first quartile. We explored the relationship between genetic variation in three key telomere pathway genes (POT1, TERF1, and TERT), STL, and semen parameters. STL levels were significantly higher in individuals carrying the POT1 rs1034794 mutant allele than in type individuals (β = 6.17, P = 0.005). We observed that the POT1 rs1034794 and rs10250202 variants were negatively correlated with total sperm count (β=-64.47), progressive motility (β1=-9.76; β2=-6.99), and total vitality percentage (β1=-11.80; β2=-7.04). The TERT rs2735940 variant was negatively correlated with Wobble (WOB) and Linearity (LIN). There is a non-linear relationship between STL and sperm concentration as well as total sperm count. STL may serve as potentially reliable biomarker of semen quality. Furthermore, single nucleotide polymorphisms (SNPs) in telomere-associated pathway genes (POT1, TERT) were significantly associated with sperm parameters and STL. This suggests a novel hypothesis thought polymorphisms in telomere pathway genes may indirectly regulate semen parameters by affecting STL.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.