ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Neuromodulation and cognition in late-life depression.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neuropsychiatric illness in the later years of life: summary and synthesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-life depression (LLD) is associated with cognitive decline and increased risk of dementia. Emerging evidence indicates that impaired cortical synaptic plasticity (due to multiple causes including genetic, developmental, neurodegenerative, vascular conditions, chronic stress, and chronic inflammation) may drive this vulnerability. We focus on how disruptions in prefrontal cortex plasticity related to depression contribute to dementia risk and review plasticity-inducing non-surgical neuromodulations. These neuromodulations include electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), transcranial electrical stimulation (tES), and focused ultrasound (FUS). These strategies could promote cortical plasticity and, in turn, improve network connectivity and prefrontal function, potentially reducing cognitive decline. Then, we discuss future directions that prioritize personalized, mechanism-based interventions, and use preclinical models to optimize neuromodulation protocols. These approaches aim to address the heterogeneity of LLD and improve outcomes by tailoring treatments based on individual characteristics.
Identifiers
41545465What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.