Prediction of left ventricular systolic dysfunction in left bundle branch block using a fine-tuned ECG foundation model.

Left bundle branch block (LBBB) is an important electrocardiographic (ECG) finding strongly associated with left ventricular systolic dysfunction (LVSD), a condition linked to poor clinical outcomes. Although early LVSD detection is crucial, standard diagnosis via echocardiography may not always be immediately accessible. In this study, we propose a fine-tuned ECG foundation model (FM) to enhance LVSD detection specifically in patients with LBBB. We conducted a retrospective multicenter analysis of 2,031 paired ECG-echocardiographic datasets from 892 LBBB patients. The ECG-FM was fine-tuned for optimal LVSD prediction and compared against baseline models, which were conventional deep learning methods, including Fully Convolutional Network (FCN), LSTM-FCN, ResNet, and InceptionTime. The proposed ECG-FM with single-step full fine-tuning outperformed baseline models, achieving accuracy, sensitivity, and AUROC of 0.758, 0.771, and 0.807, respectively. Additionally, sequential partial fine-tuning exhibited the highest sensitivity (0.787), enhancing screening capability. DeepLIFT analysis identified QRS complex and T wave features in leads V1–V4 as critical predictive factors. Our results demonstrated that the recommended fine-tuned ECG-FM significantly improves LBBB patient LVSD detection, potentially enabling earlier clinical diagnosis in such cases when echocardiography is not readily available, thereby potentially improving patient outcomes and clinical management.