Evidence map›Paper›PMID 41545957›Full record

ArticleBMC genomics2026

Genome assembly of Helan Shan pika (Ochotona argentata): a key resource for endangered species conservation.

Hao Meng, Haitao Fang, Kylie Blair, Melia Romine, Yun Su, Jinlian Ma, Junlan Li, Bin Liang, Ning Wang, Sangeet Lamichhaney

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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao Meng *School of Life Sciences, Inner Mongolia University, Hohhot, 010070, China.
Haitao Fang *Inner Mongolia Forestry Monitoring and Planning Institute, Hohhot, 010020, China.
Kylie BlairDepartment of Biological Sciences, Kent State University, Kent, 44240, USA.
Melia RomineSchool of Biomedical Sciences, Kent State University, Kent, OH, 44240, USA.
Yun SuHelan Mountain National Nature Reserve of Inner Mongolia, Bayanhot, 750306, China.
Jinlian MaHelan Mountain National Nature Reserve of Inner Mongolia, Bayanhot, 750306, China.
Junlan LiSchool of Life Sciences, Inner Mongolia University, Hohhot, 010070, China.
Bin LiangSchool of Life Sciences, Inner Mongolia University, Hohhot, 010070, China. binliang@imu.edu.cn.
Ning WangSchool of Life Sciences, Inner Mongolia University, Hohhot, 010070, China. ningwimu@imu.edu.cn.
Sangeet LamichhaneyDepartment of Biological Sciences, Kent State University, Kent, 44240, USA. slamichh@kent.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Helan Shan pika (Ochotona argentata), endemic to a small region in China, represents a unique case of a species with a restricted distribution that is vulnerable to anthropogenic threats and rapid environmental changes. Despite its endangered status, genomic research on O. argentata remains limited. In this study, we present the first genome assembly of O. argentata with high genome contiguity and gene-space completeness, with a total assembly size of 2.22 Gb and 24,374 annotated genes. Genome synteny analysis revealed strong sequence conservation between the O. argentata and previously sequenced American pika (O. princeps) genome, while also allowing us to characterize its sex chromosomes. Additionally, population demography analysis indicated a notable population decline in O. argentata approximately 300,000 to 500,000 years ago, coinciding with the mid-Pleistocene glacial period. Furthermore, we identified an increased genetic load in O. argentata, likely driven by its highly restricted range and low genetic diversity. Our study provides the first genomic resource for O. argentata, essential for understanding the molecular processes underlying endemism and local adaptation in the endangered Helan Shan pika.

Indexed as

Endangered SpeciesGenomeGenomicsLagomorphaAnimalsGenetic VariationMolecular Sequence AnnotationPhylogenyEndangered speciesEndemismGenetic loadGenome assemblyHelan Shan pikaLocal adaptation

Identifiers

PMID41545957
PMCPMC12895651

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.