ArticleBMC cancer2026
Response assessment of patients with locally advanced renal cell carcinoma receiving prior systemic therapy.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From trial results to bedside decisions: a time-resolved view of CheckMate-9ER.Translational andrology and urology · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLocally advanced renal cell carcinoma (RCC) without distant metastases remains challenging to treat surgically, especially when venous tumor thrombus is present. Neoadjuvant checkpoint inhibitor (CPI) and tyrosine kinase inhibitor (TKI) therapy may downstage tumors and improve resectability, but evidence is limited. This study evaluated radiographic and pathological responses, surgical feasibility, and safety following preoperative systemic therapy.
methodsThis single-center retrospective analysis of 17 patients with non-metastatic RCC who received ≥ 1 month of CPI, TKI, or CPI + TKI before nephrectomy. Tumor stage, radiographic tumor/thrombus reduction, pathological viable tumor percentage, surgical outcomes, complications by Clavien-Dindo, and disease-free survival (DFS) were collected.
resultsMedian pretreatment tumor diameter was 9.1 cm; 71% had venous tumor thrombus. Most patients (88%) received CPI + TKI. Median treatment duration was 7 months. Median radiographic tumor reduction was 27.1%; 50% of thrombus-bearing patients showed Mayo level reduction. Median viable tumor content was 30%; 17.6% achieved ypT0. T-stage downstaging occurred in 53%. Surgery was feasible in all cases; 17.6% experienced Clavien-Dindo grade ≥ III complications, mostly with thrombus resections. Median DFS was 28 months. No correlation between radiographic and pathological response was observed. Limitations include retrospective single-center design, small sample size, and limited follow-up/events, restricting generalizability and survival analyses.
conclusionPreoperative CPI + TKI therapy in selected non-metastatic RCC patients is associated with measurable tumor and thrombus regression without compromising surgical safety. These findings support further prospective trials to clarify long-term oncologic benefit and identify predictors of response to integrate neoadjuvant therapy into multidisciplinary RCC care.
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